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Hypoxia inducible factor 3, alpha subunit
Symbols HIF3A ; HIF-3A; IPAS; MOP7; PASD7; bHLHe17
External IDs OMIM609976 MGI1859778 HomoloGene9646 GeneCards: HIF3A Gene
RNA expression pattern
PBB GE HIF3A 222123 s at tn.png
PBB GE HIF3A 219319 at tn.png
More reference expression data
Species Human Mouse
Entrez 64344 53417
Ensembl ENSG00000124440 ENSMUSG00000004328
UniProt Q9Y2N7 Q0VBL6
RefSeq (mRNA) NM_022462 NM_001162950
RefSeq (protein) NP_071907 NP_001156422
Location (UCSC) Chr 19:
46.8 – 46.85 Mb
Chr 7:
17.03 – 17.06 Mb
PubMed search [1] [2]

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.[1][2][3]

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.[3]

DNA methylation in the introns of HIF3A is associated with BMI an adiposity [4]

See also[edit]


  1. ^ Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (Sep 2001). "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha". Biochem Biophys Res Commun 287 (4): 808–13. doi:10.1006/bbrc.2001.5659. PMID 11573933. 
  2. ^ Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L (Dec 2001). "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression". Nature 414 (6863): 550–4. doi:10.1038/35107085. PMID 11734856. 
  3. ^ a b "Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit". 
  4. ^ http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2962674-4/abstract

Further reading[edit]