SOX11
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| SRY (sex determining region Y)-box 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SOX11; | ||||||||||||
| External IDs | OMIM: 600898 MGI: 98359 HomoloGene: 37733 GeneCards: SOX11 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6664 | 20666 | |||||||||||
| Ensembl | ENSG00000176887 | ENSMUSG00000063632 | |||||||||||
| UniProt | P35716 | Q6AZA6 | |||||||||||
| RefSeq (mRNA) | XM_001128542 | NM_009234.6 | |||||||||||
| RefSeq (protein) | XP_001128542 | NP_033260.4 | |||||||||||
| Location (UCSC) | Chr 2: 5.83 – 5.84 Mb |
Chr 12: 28.03 – 28.03 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.[1][2][3]
This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.[3][4] Tuj1 and Tead2 are suggested as direct target of Sox11.[5][6]
[edit] See also
[edit] References
- ^ Jay P, Goze C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Aug 1996). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.
- ^ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". J Biol Chem 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.
- ^ a b "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6664.
- ^ Haslinger A, Schwarz TJ, Covic M, Chichung Lie D. (May 2009). "Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis". Eur J Neurosci. 29 (11): 2103–14. doi:10.1111/j.1460-9568.2009.06768.x. PMID 19490090.
- ^ Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J. (Dec 2006). "The establishment of neuronal properties is controlled by Sox4 and Sox11". Genes Dev. 20 (24): 3475–86. doi:10.1101/gad.403406. PMC 1698453. PMID 17182872. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1698453.
- ^ Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V. (Apr 2010). "Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors". Nat Commun. 1 (1): 9. doi:10.1038/ncomms1008. PMC 2892298. PMID 20596238. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2892298.
[edit] Further reading
- Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
- Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=309692.
- Kuhlbrodt K, Herbarth B, Sock E et al (1998). "Cooperative function of POU proteins and SOX proteins in glial cells". J. Biol. Chem. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.
- Azuma T, Ao S, Saito Y et al (2000). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Res. 6 (5): 357–60. doi:10.1093/dnares/6.5.357. PMID 10574465.
- Lee CJ, Appleby VJ, Orme AT et al (2003). "Differential expression of SOX4 and SOX11 in medulloblastoma". J. Neurooncol. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ballif BA, Villén J, Beausoleil SA et al (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Bouma GJ, Albrecht KH, Washburn LL et al (2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development 132 (13): 3045–54. doi:10.1242/dev.01890. PMID 15944188.
- Thevenet L, Albrecht KH, Malki S et al (2006). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". J. Biol. Chem. 280 (46): 38625–30. doi:10.1074/jbc.M504127200. PMID 16166090.
- DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenet. Genome Res. 112 (1–2): 176–9. doi:10.1159/000087532. PMID 16276109.
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