SOX12

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SRY (sex determining region Y)-box 12
Identifiers
Symbols SOX12 ; SOX22
External IDs OMIM601947 MGI98360 HomoloGene5057 GeneCards: SOX12 Gene
RNA expression pattern
PBB GE SOX12 204432 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6666 20667
Ensembl ENSG00000177732 ENSMUSG00000051817
UniProt O15370 Q04890
RefSeq (mRNA) NM_006943 NM_011438
RefSeq (protein) NP_008874 NP_035568
Location (UCSC) Chr 20:
0.31 – 0.31 Mb
Chr 2:
152.39 – 152.4 Mb
PubMed search [1] [2]

SOX12 is a protein that in humans is encoded by the SOX12 gene.[1][2] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[3] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[4]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[2]

References[edit]

  1. ^ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet 6 (7): 1069–77. doi:10.1093/hmg/6.7.1069. PMID 9215677. 
  2. ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12". 
  3. ^ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363. PMID 18505825. 
  4. ^ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431. PMID 18403418. 

Further reading[edit]