HOXB6

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Homeobox B6
Protein HOXB6 PDB 1ahd.png
PDB rendering based on 1ahd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOXB6 ; HOX2; HOX2B; HU-2; Hox-2.2
External IDs OMIM142961 MGI96187 HomoloGene7366 GeneCards: HOXB6 Gene
RNA expression pattern
PBB GE HOXB6 205366 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3216 15414
Ensembl ENSG00000108511 ENSMUSG00000000690
UniProt P17509 P09023
RefSeq (mRNA) NM_018952 NM_008269
RefSeq (protein) NP_061825 NP_032295
Location (UCSC) Chr 17:
46.67 – 46.68 Mb
Chr 11:
96.29 – 96.3 Mb
PubMed search [1] [2]

Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.[3]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB6 homeobox B6". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.