FHL3

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Four and a half LIM domains 3
Protein FHL3 PDB 1wyh.png
PDB rendering based on 1wyh.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FHL3 ; SLIM2
External IDs OMIM602790 MGI1341092 HomoloGene37928 GeneCards: FHL3 Gene
RNA expression pattern
PBB GE FHL3 218818 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2275 14201
Ensembl ENSG00000183386 ENSMUSG00000032643
UniProt Q13643 Q9R059
RefSeq (mRNA) NM_001243878 NM_010213
RefSeq (protein) NP_001230807 NP_034343
Location (UCSC) Chr 1:
38.46 – 38.47 Mb
Chr 4:
124.7 – 124.71 Mb
PubMed search [1] [2]

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.[1][2][3]

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM][3]

Interactions[edit]

FHL3 has been shown to interact with FHL2,[4][5] CTBP2,[6] KLF3,[6] ITGA7[7] and CREB1.[4]

References[edit]

  1. ^ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811. 
  2. ^ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657. 
  3. ^ a b "Entrez Gene: FHL3 four and a half LIM domains 3". 
  4. ^ a b Fimia, G M; De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. ISSN 0270-7306. PMC 102166. PMID 11046156. 
  5. ^ Li, H Y; Ng E K; Lee S M; Kotaka M; Tsui S K; Lee C Y; Fung K P; Waye M M (2001). "Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. (United States) 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. ISSN 0730-2312. PMID 11135358. 
  6. ^ a b Turner, Jeremy; Nicholas Hannah; Bishop David; Matthews Jacqueline M; Crossley Merlin (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. (United States) 278 (15): 12786–95. doi:10.1074/jbc.M300587200. ISSN 0021-9258. PMID 12556451. 
  7. ^ Samson, Thomas; Smyth Neil; Janetzky Stefanie; Wendler Olaf; Müller Judith M; Schüle Roland; von der Mark Helga; von der Mark Klaus; Wixler Viktor (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. (United States) 279 (27): 28641–52. doi:10.1074/jbc.M312894200. ISSN 0021-9258. PMID 15117962. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.