ZNF217

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Zinc finger protein 217
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ZNF217 ; ZABC1
External IDs OMIM602967 MGI2685408 HomoloGene4757 GeneCards: ZNF217 Gene
RNA expression pattern
PBB GE ZNF217 203739 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7764 228913
Ensembl ENSG00000171940 ENSMUSG00000052056
UniProt O75362 Q3U0X6
RefSeq (mRNA) NM_006526 NM_001033299
RefSeq (protein) NP_006517 NP_001028471
Location (UCSC) Chr 20:
52.18 – 52.23 Mb
Chr 2:
170.11 – 170.15 Mb
PubMed search [1] [2]

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.[1][2]

Function[edit]

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[3] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.[4]

See also[edit]

References[edit]

  1. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (July 1998). "Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742. 
  2. ^ "Entrez Gene: ZNF217 zinc finger protein 217". 
  3. ^ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C (November 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Hum. Mol. Genet. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743. 
  4. ^ Littlepage, LE; Adler AS, Kouros-Mehr Hosein, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. (2012). "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression.". Cancer Discov. 2 (7): 638–51. doi:10.1158/2159-8290.CD-12-0093. PMC 3546490. PMID 22728437. 

Further reading[edit]

External links[edit]