Estrogen-related receptor

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estrogen-related receptor alpha
Identifiers
Symbol ESRRA
Alt. symbols ESRL1
Entrez 2101
HUGO 3471
OMIM 601998
RefSeq NM_004451
UniProt P11474
Other data
Locus Chr. 11 q12
estrogen-related receptor beta
Identifiers
Symbol ESRRB
Alt. symbols ESRL2
Entrez 2103
HUGO 3473
OMIM 602167
RefSeq NM_004452
UniProt O95718
Other data
Locus Chr. 14 q24.3
estrogen-related receptor gamma
Identifiers
Symbol ESRRG
Entrez 2104
HUGO 3474
OMIM 602969
RefSeq NM_206595
UniProt P62508
Other data
Locus Chr. 1 q41

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.

There are three human estrogen related receptors:


ERRs bind to estrogen response elements and modulate transcription but are not activated by estrogens. They also have their own response elements: ERREs. ERRs have been associated with energy homeostasis, diabetes and cancer.[1]

References[edit]

  1. ^ Ariazi E, Jordan V (2006). "Estrogen-related receptors as emerging targets in cancer and metabolic disorders". Curr Top Med Chem 6 (3): 203–15. doi:10.2174/156802606776173483. PMID 16515477. 

External links[edit]