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Homeobox D9
Protein HOXD9 PDB 1puf.png
PDB rendering based on 1puf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HOXD9 ; HOX4; HOX4C; Hox-4.3; Hox-5.2
External IDs OMIM142982 MGI96210 HomoloGene8409 GeneCards: HOXD9 Gene
RNA expression pattern
PBB GE HOXD9 205604 at tn.png
More reference expression data
Species Human Mouse
Entrez 3235 15438
Ensembl ENSG00000128709 ENSMUSG00000043342
UniProt P28356 P28357
RefSeq (mRNA) NM_014213 NM_013555
RefSeq (protein) NP_055028 NP_038583
Location (UCSC) Chr 2:
176.99 – 176.99 Mb
Chr 2:
74.7 – 74.7 Mb
PubMed search [1] [2]

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.[1][2][3]


This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.[3]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXD9 homeobox D9". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.