LMX1A

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LIM homeobox transcription factor 1, alpha
Identifiers
Symbols LMX1A ; LMX1; LMX1.1
External IDs OMIM600298 MGI1888519 HomoloGene24921 GeneCards: LMX1A Gene
Orthologs
Species Human Mouse
Entrez 4009 110648
Ensembl ENSG00000162761 ENSMUSG00000026686
UniProt Q8TE12 Q9JKU8
RefSeq (mRNA) NM_001033507 NM_033652
RefSeq (protein) NP_001167540 NP_387501
Location (UCSC) Chr 1:
165.17 – 165.33 Mb
Chr 1:
167.69 – 167.85 Mb
PubMed search [1] [2]

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[1][2]

Function[edit]

Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[1]

Interactions[edit]

LMX1A has been shown to interact with TCF3[3] and LHX3.[4]

References[edit]

  1. ^ a b "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha". 
  2. ^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771. 
  3. ^ Johnson, J D; Zhang W, Rudnick A, Rutter W J, German M S (Jul 1997). "Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity". Mol. Cell. Biol. (UNITED STATES) 17 (7): 3488–96. ISSN 0270-7306. PMC 232202. PMID 9199284. 
  4. ^ Jurata, L W; Pfaff S L, Gill G N (Feb 1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. (UNITED STATES) 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. ISSN 0021-9258. PMID 9452425. 

Further reading[edit]