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E4F transcription factor 1
Symbols E4F1 ; E4F
External IDs OMIM603022 MGI109530 HomoloGene3259 GeneCards: E4F1 Gene
RNA expression pattern
PBB GE E4F1 218524 at tn.png
More reference expression data
Species Human Mouse
Entrez 1877 13560
Ensembl ENSG00000167967 ENSMUSG00000024137
UniProt Q66K89 Q8CCE9
RefSeq (mRNA) NM_001288776 NM_007893
RefSeq (protein) NP_001275705 NP_031919
Location (UCSC) Chr 16:
2.27 – 2.29 Mb
Chr 17:
24.44 – 24.46 Mb
PubMed search [1] [2]

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]


E4F1 has been shown to interact with P16,[4] Retinoblastoma protein[5] and P53.[4][6]


  1. ^ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet 82 (1-2): 99–100. doi:10.1159/000015075. PMID 9763670. 
  2. ^ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res 6 (6): 525–37. doi:10.1101/gr.6.6.525. PMID 8828041. 
  3. ^ a b "Entrez Gene: E4F1 E4F transcription factor 1". 
  4. ^ a b Rizos, Helen; Diefenbach Eve; Badhwar Prerna; Woodruff Sarah; Becker Therese M; Rooney Robert J; Kefford Richard F (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. (United States) 278 (7): 4981–9. doi:10.1074/jbc.M210978200. ISSN 0021-9258. PMID 12446718. 
  5. ^ Fajas, L; Paul C; Zugasti O; Le Cam L; Polanowska J; Fabbrizio E; Medema R; Vignais M L; Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7738–43. doi:10.1073/pnas.130198397. ISSN 0027-8424. PMC 16614. PMID 10869426. 
  6. ^ Sandy, P; Gostissa M; Fogal V; Cecco L D; Szalay K; Rooney R J; Schneider C; Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene (ENGLAND) 19 (2): 188–99. doi:10.1038/sj.onc.1203250. ISSN 0950-9232. PMID 10644996. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.