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General transcription factor IIH, polypeptide 4, 52kDa
Symbols GTF2H4 ; P52; TFB2; TFIIH
External IDs OMIM601760 MGI1338799 HomoloGene7090 GeneCards: GTF2H4 Gene
RNA expression pattern
PBB GE GTF2H4 203577 at tn.png
More reference expression data
Species Human Mouse
Entrez 2968 14885
Ensembl ENSG00000213780 ENSMUSG00000001524
UniProt Q92759 O70422
RefSeq (mRNA) NM_001517 NM_010364
RefSeq (protein) NP_001508 NP_034494
Location (UCSC) Chr 6:
30.88 – 30.88 Mb
Chr 17:
35.67 – 35.67 Mb
PubMed search [1] [2]

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.[1][2]


GTF2H4 has been shown to interact with MED21,[3] GTF2F1,[3] TATA binding protein,[3] XPB,[1][4] POLR2A[3] and Transcription Factor II B.[3]

See also[edit]


  1. ^ a b Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947. 
  2. ^ "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa". 
  3. ^ a b c d e Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119. 
  4. ^ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. (United States) 36 (7): 714–9. doi:10.1038/ng1387. ISSN 1061-4036. PMID 15220921. 

Further reading[edit]

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