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Zinc finger protein 74
Symbols ZNF74 ; COS52; ZFP520; ZNF520; hZNF7
External IDs OMIM194548 HomoloGene88675 GeneCards: ZNF74 Gene
RNA expression pattern
PBB GE ZNF74 205881 at tn.png
More reference expression data
Species Human Mouse
Entrez 7625 n/a
Ensembl ENSG00000185252 n/a
UniProt Q16587 n/a
RefSeq (mRNA) NM_001256523 n/a
RefSeq (protein) NP_001243452 n/a
Location (UCSC) Chr 22:
20.75 – 20.76 Mb
PubMed search [1] n/a

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3] Schizophrenia susceptibility has been associated with a mutation in this protein.[4]


ZNF74 has been shown to interact with POLR2A.[5]


  1. ^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O et al. (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ "Entrez Gene: ZNF74 zinc finger protein 74". 
  4. ^ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia" 52 (3). pp. 161–165. 
  5. ^ Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.