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Zinc finger protein 74
Symbols ZNF74 ; COS52; ZFP520; ZNF520; hZNF7
External IDs OMIM194548 HomoloGene88675 GeneCards: ZNF74 Gene
RNA expression pattern
PBB GE ZNF74 205881 at tn.png
More reference expression data
Species Human Mouse
Entrez 7625 n/a
Ensembl ENSG00000185252 n/a
UniProt Q16587 n/a
RefSeq (mRNA) NM_001256523 n/a
RefSeq (protein) NP_001243452 n/a
Location (UCSC) Chr 22:
20.75 – 20.76 Mb
PubMed search [1] n/a

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3] Schizophrenia susceptibility has been associated with a mutation in this protein.[4]


ZNF74 has been shown to interact with POLR2A.[5]


  1. ^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ "Entrez Gene: ZNF74 zinc finger protein 74". 
  4. ^ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia" 52 (3). pp. 161–165. 
  5. ^ Grondin, B; Côté F; Bazinet M; Vincent M; Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. (UNITED STATES) 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. ISSN 0021-9258. PMID 9346935. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.