This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
^Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Aug 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Curr Biol8 (9): 508–15. doi:10.1016/S0960-9822(98)70202-7. PMID9560339.
Sridharan R, Smale ST (2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.". J. Biol. Chem.282 (41): 30227–38. doi:10.1074/jbc.M702541200. PMID17681952.
Nakase K, Ishimaru F, Fujii K, et al. (2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.". Exp. Hematol.30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID11937265.
Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.". J. Biol. Chem.275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID10978333.
Hosokawa Y, Maeda Y, Seto M (1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern.". Immunogenetics50 (1-2): 106–8. doi:10.1007/s002510050696. PMID10541817.