From Wikipedia, the free encyclopedia
Jump to: navigation, search
Homeobox D3
Symbols HOXD3 ; HOX1D; HOX4; HOX4A; Hox-4.1
External IDs OMIM142980 MGI96207 HomoloGene5034 GeneCards: HOXD3 Gene
RNA expression pattern
PBB GE HOXD3 206602 s at tn.png
PBB GE HOXD3 206601 s at tn.png
PBB GE HOXD3 217076 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3232 15434
Ensembl ENSG00000128652 ENSMUSG00000079277
UniProt P31249 P09027
RefSeq (mRNA) NM_006898 NM_010468
RefSeq (protein) NP_008829 NP_034598
Location (UCSC) Chr 2:
177 – 177.04 Mb
Chr 2:
74.71 – 74.75 Mb
PubMed search [1] [2]

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[3]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXD3 homeobox D3". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.