USF1

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For the failed Formula One team, see US F1 Team.
Upstream transcription factor 1
Protein USF1 PDB 1an4.png
PDB rendering based on 1an4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols USF1 ; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI; UEF; bHLHb11
External IDs OMIM191523 MGI99542 HomoloGene31426 GeneCards: USF1 Gene
Orthologs
Species Human Mouse
Entrez 7391 22278
Ensembl ENSG00000158773 ENSMUSG00000026641
UniProt P22415 Q61069
RefSeq (mRNA) NM_001276373 NM_009480
RefSeq (protein) NP_001263302 NP_033506
Location (UCSC) Chr 1:
161.01 – 161.02 Mb
Chr 1:
171.41 – 171.42 Mb
PubMed search [1] [2]

Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.[1][2]

This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]

Interactions[edit]

USF1 (human gene) has been shown to interact with USF2,[3][4] FOSL1[5] and GTF2I.[6][7]

References[edit]

  1. ^ Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Jun 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371. 
  2. ^ a b "Entrez Gene: USF1 upstream transcription factor 1". 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Viollet, B; Lefrançois-Martinez A M; Henrion A; Kahn A; Raymondjean M; Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". J. Biol. Chem. (UNITED STATES) 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. ISSN 0021-9258. PMID 8576131. 
  5. ^ Pognonec, P; Boulukos K E; Aperlo C; Fujimoto M; Ariga H; Nomoto A; Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene (ENGLAND) 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. ISSN 0950-9232. PMID 9160889. 
  6. ^ Roy, A L; Du H; Gregor P D; Novina C D; Martinez E; Roeder R G (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". EMBO J. (ENGLAND) 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. ISSN 0261-4189. PMC 1170311. PMID 9384587. 
  7. ^ Roy, A L; Meisterernst M; Pognonec P; Roeder R G (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature (ENGLAND) 354 (6350): 245–8. doi:10.1038/354245a0. ISSN 0028-0836. PMID 1961251. 

Further reading[edit]

External links[edit]