BCL11B

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B-cell CLL/lymphoma 11B (zinc finger protein)
Identifiers
Symbols BCL11B ; ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; RIT1; ZNF856B; hRIT1-alpha
External IDs OMIM606558 MGI1929913 HomoloGene10974 GeneCards: BCL11B Gene
RNA expression pattern
PBB GE BCL11B 219528 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64919 58208
Ensembl ENSG00000127152 ENSMUSG00000048251
UniProt Q9C0K0 Q99PV8
RefSeq (mRNA) NM_001282237 NM_001079883
RefSeq (protein) NP_001269166 NP_001073352
Location (UCSC) Chr 14:
99.64 – 99.74 Mb
Chr 12:
107.91 – 108 Mb
PubMed search [1] [2]

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[1][2][3]

Function[edit]

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[3]

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.[4]

Interactions[edit]

BCL11B has been shown to interact with COUP-TFI.[5]

References[edit]

  1. ^ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ (Nov 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood 98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID 11719382. 
  2. ^ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B Jr, Martinez B, Crofoot K, Filtz TM, Leid M (Oct 2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". J Biol Chem 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMC 2547407. PMID 16950772. 
  3. ^ a b "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)". 
  4. ^ Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4278–83. doi:10.1073/pnas.0900568106. PMC 2657370. PMID 19251658. Lay summaryBBC News. 
  5. ^ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.