IRX1: Difference between revisions
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== Role in Development == |
== Role in Development == |
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''IRX1'' is a member of the [[Iroquois homeobox factor|Iroquois homeobox]] gene family. Members of this family |
''IRX1'' is a member of the [[Iroquois homeobox factor|Iroquois homeobox]] gene family. Members of this family play multiple roles during pattern formation in embryos of numerous vertebrate and invertebrate species.<ref name="entrez"/> <ref>{{cite journal|last=Kerner|first=P|coauthors=Ikmi A, Coen D, Vervoort M|title=Evolutionary history of the iroquois/Irx genes in metazoans.|journal=BMC Evolutionary Biology|date=April 15, 2009|volume=9|issue=74|doi=10.1186/1471-2148-9-74|pmid=19368711|url=http://www.biomedcentral.com.ezp2.lib.umn.edu/1471-2148/9/74|accessdate=May 2014}}</ref> IRO genes are thought to function early in development to define large territories, and again later in development for further patterning specification. Experimental data suggest roles for IRX1 in vertebrates may include development and patterning of lungs, limbs, heart, eyes, and nervous system. |
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== Gene == |
== Gene == |
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Revision as of 22:46, 17 May 2014
Template:PBB Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene.[1][2] All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain fold and a characteristic IRO sequence motif.[3] Members of this family are known to play numerous roles in early embryo patterning. [1] IRX1 is has also been shown to act as a tumor suppressor gene in several forms of cancer. [4] [5] [6] [7]
Role in Development
IRX1 is a member of the Iroquois homeobox gene family. Members of this family play multiple roles during pattern formation in embryos of numerous vertebrate and invertebrate species.[1] [8] IRO genes are thought to function early in development to define large territories, and again later in development for further patterning specification. Experimental data suggest roles for IRX1 in vertebrates may include development and patterning of lungs, limbs, heart, eyes, and nervous system.
Gene
Overview
Gene Neighborhood
Expression
Protein
Properties & Characteristics
Protein Interactions
Conservation
Orthologs
Paralogs
References
- ^ a b c "Entrez Gene: iroquois homeobox 1".
- ^ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Cavodeassi, Florencia (August 1, 2001). "The Iroquois family of genes: from body building to neural patterning". Development. 128 (15): 2847–2855. PMID 11532909. Retrieved May 2014.
{{cite journal}}: Check date values in:|accessdate=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Bennett, KL (2008). "Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma". Cancer Research. 66 (12): 4494–4499. doi:10.1158/0008-5472.CAN-07-6509. PMID 18559491. Retrieved February 2014.
{{cite journal}}: Check date values in:|accessdate=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Marcinkiewicz, KM (Jan 2014). "Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells". Experimental Cell Research. 320 (1): 128–143. doi:10.1016/j.yexcr.2013.09.011. PMID 24076275. Retrieved February 2014.
{{cite journal}}: Check date values in:|accessdate=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Guo, X. (2010). "Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma". Oncogene. 29 (27): 3908–3920. doi:doi:10.1038/onc.2010.143. PMID 20440264. Retrieved February 2014.
{{cite journal}}: Check|doi=value (help); Check date values in:|accessdate=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Park, SH (Apr 2013). "Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis". Molecule and Cells. 35 (4): 298–304. doi:10.1007/s10059-013-2302-0. PMID 23456299. Retrieved February 2014.
{{cite journal}}: Check date values in:|accessdate=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Kerner, P (April 15, 2009). "Evolutionary history of the iroquois/Irx genes in metazoans". BMC Evolutionary Biology. 9 (74). doi:10.1186/1471-2148-9-74. PMID 19368711. Retrieved May 2014.
{{cite journal}}: Check date values in:|accessdate=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)CS1 maint: unflagged free DOI (link)
Further reading
- Lam CY, Tam PO, Fan DS; et al. (2008). "A genome-wide scan maps a novel high myopia locus to 5p15". Invest. Ophthalmol. Vis. Sci. 49 (9): 3768–78. doi:10.1167/iovs.07-1126. PMID 18421076.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Cirulli ET, KasperaviÄiÅ«tÄ— D, Attix DK; et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–20. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
{{cite journal}}: C1 control character in|author=at position 23 (help); Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Trynka G, Zhernakova A, Romanos J; et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Lewis MT, Ross S, Strickland PA; et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Bennett KL, Karpenko M, Lin MT; et al. (2008). "Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma". Cancer Res. 68 (12): 4494–9. doi:10.1158/0008-5472.CAN-07-6509. PMID 18559491.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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