HIVEP2

HIVEP2
Identifiers
Aliases	HIVEP2, HIV-EP2, MBP-2, MIBP1, SHN2, ZAS2, ZNF40B, human immunodeficiency virus type I enhancer binding protein 2, MRD43
External IDs	OMIM: 143054; MGI: 1338076; HomoloGene: 4900; GeneCards: HIVEP2; OMA:HIVEP2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q24.2 Start 142,751,467 bp End 142,956,698 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A2 Start 13,966,075 bp End 14,151,374 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii vena cava lateral nuclear group of thalamus saphenous vein frontal pole synovial joint pons cerebellar vermis body of tongue endothelial cell Top expressed in primary motor cortex Region I of hippocampus proper prefrontal cortex barrel cortex aortic valve visual cortex perirhinal cortex subiculum primary visual cortex hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process multicellular organism development regulation of transcription, DNA-templated transcription by RNA polymerase II signal transduction transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3097 15273 Ensembl ENSG00000010818 ENSMUSG00000015501 UniProt P31629 Q3UHF7 RefSeq (mRNA) NM_006734 NM_010437 NM_001358782 NM_001358783 RefSeq (protein) NP_006725 NP_034567 NP_001345711 NP_001345712 Location (UCSC) Chr 6: 142.75 – 142.96 Mb Chr 10: 13.97 – 14.15 Mb PubMed search
Wikidata
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Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.

Function

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

Further reading

• van 't Veer LJ, Lutz PM, Isselbacher KJ, Bernards R (October 1992). "Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 8971–5. Bibcode:1992PNAS...89.8971V. doi:10.1073/pnas.89.19.8971. PMC 50046. PMID 1409593.
• Rustgi AK, Van 't Veer LJ, Bernards R (November 1990). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America. 87 (22): 8707–10. Bibcode:1990PNAS...87.8707R. doi:10.1073/pnas.87.22.8707. PMC 55028. PMID 2247438.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Dörflinger U, Pscherer A, Moser M, Rümmele P, Schüle R, Buettner R (May 1999). "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain". Molecular and Cellular Biology. 19 (5): 3736–47. doi:10.1128/mcb.19.5.3736. PMC 84194. PMID 10207097.
• Zajac-Kaye M, Ben-Baruch N, Kastanos E, Kaye FJ, Allegra C (February 2000). "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells". The Biochemical Journal. 345 (3): 535–41. doi:10.1042/0264-6021:3450535. PMC 1220788. PMID 10642512.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• HIVEP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.