IRX5

IRX5
Identifiers
Aliases	IRX5, HMMS, IRX-2a, IRXB2, iroquois homeobox 5
External IDs	OMIM: 606195 GeneCards: IRX5
Gene location (Human) Chr. Chromosome 16 (human) Band 16q12.2 Start 54,930,865 bp End 54,934,485 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell skin of abdomen right ventricle lactiferous duct parotid gland vulva minor salivary glands left ventricle nipple tibia n/a More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding vitamin D binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process retinal bipolar neuron differentiation regulation of gene expression embryonic cranial skeleton morphogenesis regulation of transcription, DNA-templated gonad development cell development transcription, DNA-templated regulation of heart rate visual perception neuron maturation response to stimulus regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10265 n/a Ensembl ENSG00000176842 n/a UniProt P78411 n/a RefSeq (mRNA) NM_001252197 NM_005853 n/a RefSeq (protein) NP_001239126 NP_005844 n/a Location (UCSC) Chr 16: 54.93 – 54.93 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.

Function

IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.

Further reading

• Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
• Bruneau BG (2006). "[Irx5: a transcription factor that regulates the cardiac repolarization gradient]". Med Sci (Paris). 22 (3): 231–2. doi:10.1051/medsci/2006223231. PMID 16527195.
• Myrthue A, Rademacher BL, Pittsenbarger J, et al. (2008). "The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells". Clin. Cancer Res. 14 (11): 3562–70. doi:10.1158/1078-0432.CCR-07-4649. PMID 18519790.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kanno S, Kuzuoka H, Sasao S, et al. (2007). "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses". EMBO J. 26 (8): 2094–103. doi:10.1038/sj.emboj.7601663. PMC 1852789. PMID 17396150.

External links

• IRX5 human gene location in the UCSC Genome Browser.
• IRX5 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.