Neuron-derived orphan receptor 1

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Nuclear receptor subfamily 4, group A, member 3
Protein NR4A3 PDB 1cit.png
PDB rendering based on 1cit.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NR4A3 ; CHN; CSMF; MINOR; NOR1; TEC
External IDs OMIM600542 MGI1352457 HomoloGene5074 IUPHAR: NR4A3 GeneCards: NR4A3 Gene
RNA expression pattern
PBB GE NR4A3 207978 s at tn.png
PBB GE NR4A3 209959 at tn.png
PBB GE NR4A3 216979 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8013 18124
Ensembl ENSG00000119508 ENSMUSG00000028341
UniProt Q92570 Q9QZB6
RefSeq (mRNA) NM_006981 NM_015743
RefSeq (protein) NP_008912 NP_056558
Location (UCSC) Chr 9:
102.58 – 102.63 Mb
Chr 4:
48.05 – 48.09 Mb
PubMed search [1] [2]

The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.[1] NOR1 is a member of the nuclear receptor family of intracellular transcription factors.

NOR1 plays a central regulatory role in cell proliferation, differentiation, metabolism[2][3] and apoptosis[4]

Interactions[edit]

Neuron-derived orphan receptor 1 has been shown to interact with SIX3.[5][6]

See also[edit]

References[edit]

  1. ^ Hedvat CV, Irving SG (1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Mol. Endocrinol. 9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID 8614405. 
  2. ^ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967. 
  3. ^ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999. 
  4. ^ Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (2006). "The NR4A Orphan Nuclear Receptor NOR1 Is Induced by Platelet-derived Growth Factor and Mediates Vascular Smooth Muscle Cell Proliferation". J. Biol. Chem. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMC 1829169. PMID 16945922. 
  5. ^ Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (January 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Res. 63 (2): 449–54. PMID 12543801. 
  6. ^ Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Dev. Neurosci. 23 (1): 17–24. doi:10.1159/000048692. PMID 11173923. 

Further reading[edit]

  • Ohkura N, Hijikuro M, Yamamoto A, Miki K (1995). "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells". Biochem. Biophys. Res. Commun. 205 (3): 1959–65. doi:10.1006/bbrc.1994.2900. PMID 7811288. 
  • Clark J, Benjamin H, Gill S, et al. (1996). "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma". Oncogene 12 (2): 229–35. PMID 8570200. 
  • Labelle Y, Zucman J, Stenman G, et al. (1996). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation". Hum. Mol. Genet. 4 (12): 2219–26. doi:10.1093/hmg/4.12.2219. PMID 8634690. 
  • Ohkura N, Ito M, Tsukada T, et al. (1996). "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family". Biochim. Biophys. Acta 1308 (3): 205–14. doi:10.1016/0167-4781(96)00101-7. PMID 8809112. 
  • Ohkura N, Ito M, Tsukada T, et al. (1998). "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA". Gene 211 (1): 79–85. doi:10.1016/S0378-1119(98)00095-X. PMID 9573341. 
  • Labelle Y, Bussières J, Courjal F, Goldring MB (1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator". Oncogene 18 (21): 3303–8. doi:10.1038/sj.onc.1202675. PMID 10359536. 
  • Panagopoulos I, Mencinger M, Dietrich CU, et al. (2000). "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11)". Oncogene 18 (52): 7594–8. doi:10.1038/sj.onc.1203155. PMID 10602519. 
  • Sjögren H, Wedell B, Meis-Kindblom JM, et al. (2001). "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)". Cancer Res. 60 (24): 6832–5. PMID 11156374. 
  • Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–7. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795. 
  • Rius J, Martínez-González J, Crespo J, Badimon L (2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB". Arterioscler. Thromb. Vasc. Biol. 24 (4): 697–702. doi:10.1161/01.ATV.0000121570.00515.dc. PMID 14962944. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. 
  • Hisaoka M, Okamoto S, Yokoyama K, Hashimoto H (2004). "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes". Cancer Genet. Cytogenet. 152 (2): 101–7. doi:10.1016/j.cancergencyto.2003.11.011. PMID 15262426. 
  • Laflamme C, Filion C, Labelle Y (2005). "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1". Hum. Mutat. 24 (6): 502–8. doi:10.1002/humu.20102. PMID 15523651. 
  • Rius J, Martínez-González J, Crespo J, Badimon L (2006). "NOR-1 is involved in VEGF-induced endothelial cell growth". Atherosclerosis 184 (2): 276–82. doi:10.1016/j.atherosclerosis.2005.04.008. PMID 15949808. 
  • Pei L, Castrillo A, Chen M, et al. (2005). "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli". J. Biol. Chem. 280 (32): 29256–62. doi:10.1074/jbc.M502606200. PMID 15964844. 
  • Bonta PI, van Tiel CM, Vos M, et al. (2006). "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses". Arterioscler. Thromb. Vasc. Biol. 26 (10): 2288–94. doi:10.1161/01.ATV.0000238346.84458.5d. PMID 16873729. 
  • Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967. 
  • Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999. 
  • Vacca M, Murzilli S, Salvatore S, et al. (2013). "Neuron-derived orphan receptor 1 promotes proliferation of quiescent hepatocytes". Gastroenterology 144 (7): 1518–1529. doi:10.1053/j.gastro.2013.02.027. PMID 23462179. 

External links[edit]