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The [[protein]] encoded by this gene is a [[transcription factor]] that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.<ref name="pmid3499668">{{cite journal | vauthors = Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR | title = Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters | journal = Science | volume = 238 | issue = 4827 | pages = 688–92 | date = Oct 1987 | pmid = 3499668 | doi = 10.1126/science.3499668 }}</ref>
The [[protein]] encoded by this gene is a [[transcription factor]] that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.<ref name="pmid3499668">{{cite journal | vauthors = Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR | title = Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters | journal = Science | volume = 238 | issue = 4827 | pages = 688–92 | date = Oct 1987 | pmid = 3499668 | doi = 10.1126/science.3499668 }}</ref>

== Function ==
HNF-1α is a transcription factor expressed in organs of endoderm origin, including liver, kidneys, pancreas, intestines, stomach, spleen, thymus, testis, and keratinocytes and melanocytes in human skin.<ref>{{Cite journal|last=Real Hernandez|first=Luis M.|last2=Fan|first2=Junfeng|last3=Johnson|first3=Michelle H.|last4=Gonzalez de Mejia|first4=Elvira|date=2015-01-01|title=Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α|url=https://www.ncbi.nlm.nih.gov/pubmed/26413797|journal=PloS One|volume=10|issue=9|pages=e0138768|doi=10.1371/journal.pone.0138768|issn=1932-6203|pmc=4587667|pmid=26413797}}</ref> It has been shown to affect intestinal epithelial cell growth and cell lineages differentiation. For instance, HNF1A is an important cell-intrinsic transcription factor in adult B lymphopoiesis.<ref>{{Cite journal|last=Lussier|first=Carine R.|last2=Brial|first2=François|last3=Roy|first3=Sébastien A. B.|last4=Langlois|first4=Marie-Josée|last5=Verdu|first5=Elena F.|last6=Rivard|first6=Nathalie|last7=Perreault|first7=Nathalie|last8=Boudreau|first8=François|date=2010-01-01|title=Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation|url=https://www.ncbi.nlm.nih.gov/pubmed/20808783|journal=PloS One|volume=5|issue=8|pages=e12378|doi=10.1371/journal.pone.0012378|issn=1932-6203|pmc=2927538|pmid=20808783}}</ref><ref>{{Cite journal|last=D'Angelo|first=Anna|last2=Bluteau|first2=Olivier|last3=Garcia-Gonzalez|first3=Miguel A.|last4=Gresh|first4=Lionel|last5=Doyen|first5=Antonia|last6=Garbay|first6=Serge|last7=Robine|first7=Sylvie|last8=Pontoglio|first8=Marco|date=2010-05-01|title=Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium|url=https://www.ncbi.nlm.nih.gov/pubmed/20388655|journal=Development (Cambridge, England)|volume=137|issue=9|pages=1573–1582|doi=10.1242/dev.044420|issn=1477-9129|pmid=20388655}}</ref><ref>{{Cite journal|last=von Wnuck Lipinski|first=Karin|last2=Sattler|first2=Katherine|last3=Peters|first3=Susann|last4=Weske|first4=Sarah|last5=Keul|first5=Petra|last6=Klump|first6=Hannes|last7=Heusch|first7=Gerd|last8=Göthert|first8=Joachim R.|last9=Levkau|first9=Bodo|date=2016-02-15|title=Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice|url=https://www.ncbi.nlm.nih.gov/pubmed/26800876|journal=Journal of Immunology (Baltimore, Md.: 1950)|volume=196|issue=4|pages=1655–1665|doi=10.4049/jimmunol.1500897|issn=1550-6606|pmid=26800876}}</ref> The participation of HNF-1α in glucose metabolism and diabetes has been reported, including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting enzyme 2 gene expression in pancreatic islets.<ref>{{Cite journal|last=Luni|first=Camilla|last2=Marth|first2=Jamey D.|last3=Doyle|first3=Francis J.|date=2012-01-01|title=Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes|url=https://www.ncbi.nlm.nih.gov/pubmed/23300881|journal=PloS One|volume=7|issue=12|pages=e53130|doi=10.1371/journal.pone.0053130|issn=1932-6203|pmc=3531366|pmid=23300881}}</ref><ref>{{Cite journal|last=Pedersen|first=Kim Brint|last2=Chhabra|first2=Kavaljit H.|last3=Nguyen|first3=Van K.|last4=Xia|first4=Huijing|last5=Lazartigues|first5=Eric|date=2013-11-01|title=The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs|url=https://www.ncbi.nlm.nih.gov/pubmed/24100303|journal=Biochimica Et Biophysica Acta|volume=1829|issue=11|pages=1225–1235|doi=10.1016/j.bbagrm.2013.09.007|issn=0006-3002|pmc=3838857|pmid=24100303}}</ref> HNF-1α could promote the transcription of several proteins involved in the management of type II diabetes including dipeptidyl peptidase-IV (DPP-IV/CD26).<ref>{{Cite journal|last=Gu|first=Ning|last2=Adachi|first2=Tetsuya|last3=Matsunaga|first3=Tetsuro|last4=Takeda|first4=Jun|last5=Tsujimoto|first5=Gozoh|last6=Ishihara|first6=Akihiko|last7=Yasuda|first7=Koichiro|last8=Tsuda|first8=Kinsuke|date=2006-08-04|title=Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells|url=https://www.ncbi.nlm.nih.gov/pubmed/16781669|journal=Biochemical and Biophysical Research Communications|volume=346|issue=3|pages=1016–1023|doi=10.1016/j.bbrc.2006.06.010|issn=0006-291X|pmid=16781669}}</ref><ref>{{Cite journal|last=Gu|first=Ning|last2=Tsuda|first2=Mariko|last3=Matsunaga|first3=Tetsuro|last4=Adachi|first4=Tetsuya|last5=Yasuda|first5=Koichiro|last6=Ishihara|first6=Akihiko|last7=Tsuda|first7=Kinsuke|date=2008-12-01|title=Glucose regulation of dipeptidyl peptidase IV gene expression is mediated by hepatocyte nuclear factor-1alpha in epithelial intestinal cells|url=https://www.ncbi.nlm.nih.gov/pubmed/18671716|journal=Clinical and Experimental Pharmacology & Physiology|volume=35|issue=12|pages=1433–1439|doi=10.1111/j.1440-1681.2008.05015.x|issn=1440-1681|pmid=18671716}}</ref> HNF-1α is also involved in various metabolic pathways of other organs, such as being a transcriptional regulator of bile acid transporters in the intestine and kidneys.<ref>{{Cite journal|last=Shih|first=D. Q.|last2=Bussen|first2=M.|last3=Sehayek|first3=E.|last4=Ananthanarayanan|first4=M.|last5=Shneider|first5=B. L.|last6=Suchy|first6=F. J.|last7=Shefer|first7=S.|last8=Bollileni|first8=J. S.|last9=Gonzalez|first9=F. J.|date=2001-04-01|title=Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism|url=https://www.ncbi.nlm.nih.gov/pubmed/11279518|journal=Nature Genetics|volume=27|issue=4|pages=375–382|doi=10.1038/86871|issn=1061-4036|pmid=11279518}}</ref> HNF-1α is involved in the promotion of hepatic organic cation transporters, which uptake certain classes of pharmaceuticals; hence, the loss of its function can lead to drug metabolism problems.<ref>{{Cite journal|last=O'Brien|first=Valerie P.|last2=Bokelmann|first2=Kristin|last3=Ramírez|first3=Jacqueline|last4=Jobst|first4=Karoline|last5=Ratain|first5=Mark J.|last6=Brockmöller|first6=Jürgen|last7=Tzvetkov|first7=Mladen V.|date=2013-10-01|title=Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene|url=https://www.ncbi.nlm.nih.gov/pubmed/23922447|journal=The Journal of Pharmacology and Experimental Therapeutics|volume=347|issue=1|pages=181–192|doi=10.1124/jpet.113.206359|issn=1521-0103|pmc=3781413|pmid=23922447}}</ref> In addition, HNF-1α regulates the expression of acute phase proteins, such as fibrinogen, c-reactive protein, and interleukin 1 receptor, which are involved with inflammation.<ref>{{Cite journal|last=Armendariz|first=Angela D.|last2=Krauss|first2=Ronald M.|date=2009-04-01|title=Hepatic nuclear factor 1-alpha: inflammation, genetics, and atherosclerosis|url=https://www.ncbi.nlm.nih.gov/pubmed/19280766|journal=Current Opinion in Lipidology|volume=20|issue=2|pages=106–111|issn=1473-6535|pmid=19280766}}</ref> Moreover, significantly lower levels of HNF-1α in pancreatic tumors and hepatocellular adenomas than in normal adjacent tissues was observed, suggesting that HNF-1α might play a possible tumor suppressor role.<ref>{{Cite journal|last=Luo|first=Zhaofan|last2=Li|first2=Yanan|last3=Wang|first3=Huamin|last4=Fleming|first4=Jason|last5=Li|first5=Min|last6=Kang|first6=Yaan|last7=Zhang|first7=Ran|last8=Li|first8=Donghui|date=2015-01-01|title=Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer|url=https://www.ncbi.nlm.nih.gov/pubmed/25793983|journal=PloS One|volume=10|issue=3|pages=e0121082|doi=10.1371/journal.pone.0121082|issn=1932-6203|pmc=4368635|pmid=25793983}}</ref><ref>{{Cite journal|last=Bluteau|first=Olivier|last2=Jeannot|first2=Emmanuelle|last3=Bioulac-Sage|first3=Paulette|last4=Marqués|first4=Juan Martin|last5=Blanc|first5=Jean-Frédéric|last6=Bui|first6=Hung|last7=Beaudoin|first7=Jean-Christophe|last8=Franco|first8=Dominique|last9=Balabaud|first9=Charles|date=2002-10-01|title=Bi-allelic inactivation of TCF1 in hepatic adenomas|url=https://www.ncbi.nlm.nih.gov/pubmed/12355088|journal=Nature Genetics|volume=32|issue=2|pages=312–315|doi=10.1038/ng1001|issn=1061-4036|pmid=12355088}}</ref>


== Clinical significance ==
== Clinical significance ==

Revision as of 18:44, 23 September 2016

HNF1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNF1A, HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, HNF1 homeobox A, HNF4A, HNF1alpha
External IDsOMIM: 142410; MGI: 98504; HomoloGene: 459; GeneCards: HNF1A; OMA:HNF1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6927

21405

Ensembl

ENSG00000135100

ENSMUSG00000029556

UniProt

P20823

P22361

RefSeq (mRNA)

NM_000545
NM_001306179

NM_009327

RefSeq (protein)

NP_000536
NP_001293108
NP_000536.5
NP_001293108.1

NP_033353

Location (UCSC)Chr 12: 120.98 – 121 MbChr 5: 115.09 – 115.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene.[5][6]

The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.[7]

Function

HNF-1α is a transcription factor expressed in organs of endoderm origin, including liver, kidneys, pancreas, intestines, stomach, spleen, thymus, testis, and keratinocytes and melanocytes in human skin.[8] It has been shown to affect intestinal epithelial cell growth and cell lineages differentiation. For instance, HNF1A is an important cell-intrinsic transcription factor in adult B lymphopoiesis.[9][10][11] The participation of HNF-1α in glucose metabolism and diabetes has been reported, including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting enzyme 2 gene expression in pancreatic islets.[12][13] HNF-1α could promote the transcription of several proteins involved in the management of type II diabetes including dipeptidyl peptidase-IV (DPP-IV/CD26).[14][15] HNF-1α is also involved in various metabolic pathways of other organs, such as being a transcriptional regulator of bile acid transporters in the intestine and kidneys.[16] HNF-1α is involved in the promotion of hepatic organic cation transporters, which uptake certain classes of pharmaceuticals; hence, the loss of its function can lead to drug metabolism problems.[17] In addition, HNF-1α regulates the expression of acute phase proteins, such as fibrinogen, c-reactive protein, and interleukin 1 receptor, which are involved with inflammation.[18] Moreover, significantly lower levels of HNF-1α in pancreatic tumors and hepatocellular adenomas than in normal adjacent tissues was observed, suggesting that HNF-1α might play a possible tumor suppressor role.[19][20]

Clinical significance

HNF1A mutations can cause maturity onset diabetes of the young type 3, one of the forms of "monogenic diabetes",[6] as well as hepatocellular adenoma. HNF-1 protein is present in clear cell carcinoma of ovary [21][22]

Interactions

HNF1A has been shown to interact with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135100 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029556 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (Jun 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.
  6. ^ a b Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (Apr 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nature Genetics. 9 (4): 418–23. doi:10.1038/ng0495-418. PMID 7795649.
  7. ^ Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (Oct 1987). "Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters". Science. 238 (4827): 688–92. doi:10.1126/science.3499668. PMID 3499668.
  8. ^ Real Hernandez, Luis M.; Fan, Junfeng; Johnson, Michelle H.; Gonzalez de Mejia, Elvira (2015-01-01). "Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α". PloS One. 10 (9): e0138768. doi:10.1371/journal.pone.0138768. ISSN 1932-6203. PMC 4587667. PMID 26413797.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. ^ Lussier, Carine R.; Brial, François; Roy, Sébastien A. B.; Langlois, Marie-Josée; Verdu, Elena F.; Rivard, Nathalie; Perreault, Nathalie; Boudreau, François (2010-01-01). "Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation". PloS One. 5 (8): e12378. doi:10.1371/journal.pone.0012378. ISSN 1932-6203. PMC 2927538. PMID 20808783.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ D'Angelo, Anna; Bluteau, Olivier; Garcia-Gonzalez, Miguel A.; Gresh, Lionel; Doyen, Antonia; Garbay, Serge; Robine, Sylvie; Pontoglio, Marco (2010-05-01). "Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium". Development (Cambridge, England). 137 (9): 1573–1582. doi:10.1242/dev.044420. ISSN 1477-9129. PMID 20388655.
  11. ^ von Wnuck Lipinski, Karin; Sattler, Katherine; Peters, Susann; Weske, Sarah; Keul, Petra; Klump, Hannes; Heusch, Gerd; Göthert, Joachim R.; Levkau, Bodo (2016-02-15). "Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice". Journal of Immunology (Baltimore, Md.: 1950). 196 (4): 1655–1665. doi:10.4049/jimmunol.1500897. ISSN 1550-6606. PMID 26800876.
  12. ^ Luni, Camilla; Marth, Jamey D.; Doyle, Francis J. (2012-01-01). "Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes". PloS One. 7 (12): e53130. doi:10.1371/journal.pone.0053130. ISSN 1932-6203. PMC 3531366. PMID 23300881.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. ^ Pedersen, Kim Brint; Chhabra, Kavaljit H.; Nguyen, Van K.; Xia, Huijing; Lazartigues, Eric (2013-11-01). "The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs". Biochimica Et Biophysica Acta. 1829 (11): 1225–1235. doi:10.1016/j.bbagrm.2013.09.007. ISSN 0006-3002. PMC 3838857. PMID 24100303.
  14. ^ Gu, Ning; Adachi, Tetsuya; Matsunaga, Tetsuro; Takeda, Jun; Tsujimoto, Gozoh; Ishihara, Akihiko; Yasuda, Koichiro; Tsuda, Kinsuke (2006-08-04). "Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells". Biochemical and Biophysical Research Communications. 346 (3): 1016–1023. doi:10.1016/j.bbrc.2006.06.010. ISSN 0006-291X. PMID 16781669.
  15. ^ Gu, Ning; Tsuda, Mariko; Matsunaga, Tetsuro; Adachi, Tetsuya; Yasuda, Koichiro; Ishihara, Akihiko; Tsuda, Kinsuke (2008-12-01). "Glucose regulation of dipeptidyl peptidase IV gene expression is mediated by hepatocyte nuclear factor-1alpha in epithelial intestinal cells". Clinical and Experimental Pharmacology & Physiology. 35 (12): 1433–1439. doi:10.1111/j.1440-1681.2008.05015.x. ISSN 1440-1681. PMID 18671716.
  16. ^ Shih, D. Q.; Bussen, M.; Sehayek, E.; Ananthanarayanan, M.; Shneider, B. L.; Suchy, F. J.; Shefer, S.; Bollileni, J. S.; Gonzalez, F. J. (2001-04-01). "Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism". Nature Genetics. 27 (4): 375–382. doi:10.1038/86871. ISSN 1061-4036. PMID 11279518.
  17. ^ O'Brien, Valerie P.; Bokelmann, Kristin; Ramírez, Jacqueline; Jobst, Karoline; Ratain, Mark J.; Brockmöller, Jürgen; Tzvetkov, Mladen V. (2013-10-01). "Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene". The Journal of Pharmacology and Experimental Therapeutics. 347 (1): 181–192. doi:10.1124/jpet.113.206359. ISSN 1521-0103. PMC 3781413. PMID 23922447.
  18. ^ Armendariz, Angela D.; Krauss, Ronald M. (2009-04-01). "Hepatic nuclear factor 1-alpha: inflammation, genetics, and atherosclerosis". Current Opinion in Lipidology. 20 (2): 106–111. ISSN 1473-6535. PMID 19280766.
  19. ^ Luo, Zhaofan; Li, Yanan; Wang, Huamin; Fleming, Jason; Li, Min; Kang, Yaan; Zhang, Ran; Li, Donghui (2015-01-01). "Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer". PloS One. 10 (3): e0121082. doi:10.1371/journal.pone.0121082. ISSN 1932-6203. PMC 4368635. PMID 25793983.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  20. ^ Bluteau, Olivier; Jeannot, Emmanuelle; Bioulac-Sage, Paulette; Marqués, Juan Martin; Blanc, Jean-Frédéric; Bui, Hung; Beaudoin, Jean-Christophe; Franco, Dominique; Balabaud, Charles (2002-10-01). "Bi-allelic inactivation of TCF1 in hepatic adenomas". Nature Genetics. 32 (2): 312–315. doi:10.1038/ng1001. ISSN 1061-4036. PMID 12355088.
  21. ^ Köbel M, Kalloger SE, Carrick J, Huntsman D, Asad H, Oliva E, Ewanowich CA, Soslow RA, Gilks CB (Jan 2009). "A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary". The American Journal of Surgical Pathology. 33 (1): 14–21. doi:10.1097/PAS.0b013e3181788546. PMID 18830127.
  22. ^ Offman SL, Longacre TA (Sep 2012). "Clear cell carcinoma of the female genital tract (not everything is as clear as it seems)". Advances in Anatomic Pathology. 19 (5): 296–312. doi:10.1097/PAP.0b013e31826663b1. PMID 22885379.
  23. ^ a b c d Soutoglou E, Papafotiou G, Katrakili N, Talianidis I (Apr 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". The Journal of Biological Chemistry. 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. PMID 10777539.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  24. ^ Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, Toyokuni S, Tsuda K, Seino Y (May 2002). "Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter". Diabetes. 51 (5): 1409–18. doi:10.2337/diabetes.51.5.1409. PMID 11978637.
  25. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  26. ^ Sourdive DJ, Transy C, Garbay S, Yaniv M (Apr 1997). "The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity". Nucleic Acids Research. 25 (8): 1476–84. doi:10.1093/nar/25.8.1476. PMC 146627. PMID 9092652.
  27. ^ Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ (May 2001). "Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors". Drug Metabolism and Disposition. 29 (5): 623–33. PMID 11302926.
  28. ^ Rufibach LE, Duncan SA, Battle M, Deeb SS (Jul 2006). "Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter". Journal of Lipid Research. 47 (7): 1463–77. doi:10.1194/jlr.M600082-JLR200. PMID 16603721.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  29. ^ a b Bulla GA, Kraus DM (Dec 2004). "Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression". Bioscience Reports. 24 (6): 595–608. doi:10.1007/s10540-005-2794-8. PMID 16158197.

Further reading

  • Eastman Q, Grosschedl R (Apr 1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Current Opinion in Cell Biology. 11 (2): 233–40. doi:10.1016/S0955-0674(99)80031-3. PMID 10209158.
  • Bioulac-Sage P, Blanc JF, Rebouissou S, Balabaud C, Zucman-Rossi J (May 2007). "Genotype phenotype classification of hepatocellular adenoma". World Journal of Gastroenterology. 13 (19): 2649–54. doi:10.3748/wjg.v13.i19.2649. PMID 17569132.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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