Retinoid X receptor

retinoid X receptor beta
retinoid X receptor beta
Identifiers
Symbol	RXRB
NCBI gene	6257
HGNC	10478
OMIM	180246
RefSeq	NM_021976
UniProt	P28702
Other data
Locus	Chr. 6 p21.3
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

retinoid X receptor alpha
retinoid X receptor alpha
Identifiers
Symbol	RXRA
NCBI gene	6256
HGNC	10477
OMIM	180245
RefSeq	NM_002957
UniProt	P19793
Other data
Locus	Chr. 9 q34
Structures
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Structures	Swiss-model
Domains	InterPro

retinoid X receptor gamma

Identifiers

Symbol

Other data

Chr. 1 q22-q23

Search for
Structures	Swiss-model
Domains	InterPro

The retinoid X receptor (RXR)^[1] is a type of nuclear receptor that is activated by 9-cis retinoic acid.^[2] There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma, encoded by the RXRA, RXRB, RXRG genes, respectively.

RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR,^[3] PXR, RAR, TR, and VDR.

As with other type II nuclear receptors, the RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

References

^ Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H (2006). "International Union of Pharmacology. LXIII. Retinoid X receptors". Pharmacol Rev. 58 (4): 760–72. doi:10.1124/pr.58.4.7. PMID 17132853.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA (1993). "Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids". Proc Natl Acad Sci USA. 90 (1): 30–4. doi:10.1073/pnas.90.1.30. PMC 45593. PMID 8380496.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Plutzky J (April 2011). "The PPAR-RXR transcriptional complex in the vasculature: energy in the balance". Circ. Res. 108 (8): 1002–16. doi:10.1161/CIRCRESAHA.110.226860. PMID 21493923.

External links

Retinoid+X+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

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[Germain_2006b-1] Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H (2006). "International Union of Pharmacology. LXIII. Retinoid X receptors". Pharmacol Rev. 58 (4): 760–72. doi:10.1124/pr.58.4.7. PMID 17132853.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[Allenby_1993-2] Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA (1993). "Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids". Proc Natl Acad Sci USA. 90 (1): 30–4. doi:10.1073/pnas.90.1.30. PMC 45593. PMID 8380496.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid21493923-3] Plutzky J (April 2011). "The PPAR-RXR transcriptional complex in the vasculature: energy in the balance". Circ. Res. 108 (8): 1002–16. doi:10.1161/CIRCRESAHA.110.226860. PMID 21493923.

[1]

[2]

[3]

See also

References

External links