Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.
^Won, Jaejoon; Yim Jeongbin, Kim Tae Kook (October 2002). "Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells". J. Biol. Chem. (United States) 277 (41): 38230–8. doi:10.1074/jbc.M206064200. ISSN0021-9258. PMID12151407.Cite uses deprecated parameters (help)
^Sun, Jian-Min; Chen Hou Yu, Moniwa Mariko, Litchfield David W, Seto Edward, Davie James R (September 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". J. Biol. Chem. (United States) 277 (39): 35783–6. doi:10.1074/jbc.C200378200. ISSN0021-9258. PMID12176973.Cite uses deprecated parameters (help)
^Rotheneder, H; Geymayer S, Haidweger E (November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. (ENGLAND) 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN0022-2836. PMID10547281.Cite uses deprecated parameters (help)
^Galvagni, F; Capo S, Oliviero S (March 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". J. Mol. Biol. (England) 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. ISSN0022-2836. PMID11237613.Cite uses deprecated parameters (help)
Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.". J. Steroid Biochem. Mol. Biol.85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID12943729.