BZIP domain: Difference between revisions

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The '''Basic Leucine Zipper Domain''' ('''bZIP domain''') is found in many [[DNA]] binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the [[leucine zipper]] that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as [[arginine]] and [[lysine]]. Proteins containig this domain are [[transcription factors]].
The '''Basic Leucine Zipper Domain''' ('''bZIP domain''') is found in many [[DNA]] binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the [[leucine zipper]] that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as [[arginine]] and [[lysine]]. Proteins containig this domain are [[transcription factors]].


==bZIP transcription factors==
bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded in the last recent common ancestor of all plants <ref name="pmid18698409 ">.

bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded by the genome of the [[most recent common ancestor]] of all plants <ref name="pmid18698409 ">{{cite journal |author=Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. |title=The role of bZIP transcription factors in green plant evolution: adaptive features emerging from four founder genes |journal=PLos ONE |volume=3 |issue=8 |pages=e2944 |year=2008 |pmid=18698409 |doi=10.1371/journal.pone.0002944}}</ref>.



==bZIP domain containing proteins==
==bZIP domain containing proteins==

*AP-1 [[fos]]/[[Jun (protein)|jun]] heterodimer that forms a [[transcription factor]]
*AP-1 [[fos]]/[[Jun (protein)|jun]] heterodimer that forms a [[transcription factor]]
*[[Jun-B]] transcription factor
*[[Jun-B]] transcription factor
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==External links==
==External links==
*[http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=BRLZ bZIP domain entry in the SMART database]
*[http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=BRLZ bZIP domain entry in the SMART database]
*[http://plntfdb.bio.uni-potsdam.de/v2.0/fam_mem.php?family_id=bZIP Plant bZIP transcription factors]


== References ==
== References ==

Revision as of 05:57, 18 August 2008

This article is about the protein domain. For the comression algorithm, see Bzip2.
bZIP transcription factor
CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
Identifiers
SymbolbZIP_1
PfamPF00170
InterProIPR011616
PROSITEPDOC00036
SCOP21ysa / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1dh3A:285-339 1t2kD:336-395 1s9kE:257-308

1junB:276-313 1jnmA:254-313 1a02J:257-308 1swiB:249-278 1ce9A:251-279 1uo0A:249-279 1rb5B:249-279 1unwB:249-279 1vzlB:249-279 1untA:249-279 1zimC:249-279 1w5jD:249-279 1zijA:249-279 1rb6A:249-279 2ztaA:249-279 1uo5B:249-279 1rb1C:249-279 1gclC:249-279 1w5gB:249-279 1w5iA:249-279 1uo1A:249-279 1unuB:249-279 1gcmA:249-279 1rb4C:249-279 1uo2B:249-279 1ysaD:226-279 1unzB:249-279 1w5kD:249-279 1ij1A:249-279 1zta :247-279 1ij0A:249-279 1uo3A:249-279 1w5hA:249-279 1ij2A:249-279 1dgcA:227-279 1w5lB:249-279 1unyA:249-279 2b1fB:251-279 2bniB:249-279 1zilA:249-278 1ziiA:249-279 1unvB:249-279 1zikB:249-278 1unxA:249-279 1ij3B:249-279 1uo4A:249-279 1kqlB:255-279 2dgcA:229-277 1piqA:249-279 2b22A:251-279 1lvxA:265-294

1gd2H:74-137 1ci6A:280-339

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as arginine and lysine. Proteins containig this domain are transcription factors.

bZIP transcription factors

bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants [1].


bZIP domain containing proteins

  • AP-1 fos/jun heterodimer that forms a transcription factor
  • Jun-B transcription factor
  • CREB cAMP response element transcription factor
  • OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea Mays) kernels


Human proteins containing this domain

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; NFE2; NFE2L2; NFE2L3; SNFT; CREM

External links

References

  1. ^ Corrêa LGG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M. (2008). "The role of bZIP transcription factors in green plant evolution: adaptive features emerging from four founder genes". PLos ONE. 3 (8): e2944. doi:10.1371/journal.pone.0002944. PMID 18698409.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
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