E2F1

E2F1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H24, 1O9K, 2AZE
Identifiers
Aliases	E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1
External IDs	OMIM: 189971; MGI: 101941; HomoloGene: 3828; GeneCards: E2F1; OMA:E2F1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.22 Start 33,675,477 bp End 33,686,385 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H1|2 76.79 cM Start 154,401,327 bp End 154,411,812 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence secondary oocyte ventricular zone gonad mucosa of transverse colon stromal cell of endometrium prefrontal cortex testicle bone marrow putamen Top expressed in zygote secondary oocyte ectoderm otic vesicle otic placode primary oocyte fetal liver hematopoietic progenitor cell ventricular zone saccule gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity transcription factor binding protein binding protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein kinase binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex Rb-E2F complex nucleus mitochondrion nucleoplasm centrosome protein-containing complex RNA polymerase II transcription regulator complex Biological process cellular response to nerve growth factor stimulus negative regulation of fat cell differentiation regulation of transcription, DNA-templated lens fiber cell apoptotic process negative regulation of transcription involved in G1/S transition of mitotic cell cycle positive regulation of fibroblast proliferation negative regulation of DNA binding negative regulation of fat cell proliferation DNA damage checkpoint signaling cellular response to xenobiotic stimulus negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of cell cycle positive regulation of transcription, DNA-templated regulation of G1/S transition of mitotic cell cycle mRNA stabilization positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of gene expression cellular response to fatty acid anoikis spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator cell cycle forebrain development negative regulation of transcription, DNA-templated cellular response to hypoxia positive regulation of transcription by RNA polymerase II apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of transcription involved in G1/S transition of mitotic cell cycle positive regulation of apoptotic process negative regulation of G0 to G1 transition positive regulation of glial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1869 13555 Ensembl ENSG00000101412 ENSMUSG00000027490 UniProt Q01094 Q61501 RefSeq (mRNA) NM_005225 NM_007891 NM_001291105 RefSeq (protein) NP_005216 NP_001278034 NP_031917 Location (UCSC) Chr 20: 33.68 – 33.69 Mb Chr 2: 154.4 – 154.41 Mb PubMed search
Wikidata
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Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Transcription

E2F1 promoter[PAX8] => E2F1

Interactions

E2F1 has been shown to interact with:

• ARID3A,
• CUL1,
• Cyclin A1,
• Cyclin A2,
• GTF2H1,
• MDM4,
• NCOA6,
• NDN,
• NPDC1,
• PURA,
• PHB,
• RB1,
• RBL1,
• SKP2,
• SP1,
• SP2,
• SP3,
• SP4,
• TFDP1
• TOPBP1,
• TP53BP1, and
• UBC.

See also

• E2F
• Retinoblastoma protein

Further reading

• Dupont E, Sansal I, Toru D, Evrard C, Rouget P (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Séances Soc. Biol. Fil. 191 (1): 95–104. PMID 9181131.
• Stevens C, La Thangue NB (2005). "The emerging role of E2F-1 in the DNA damage response and checkpoint control". DNA Repair (Amst.). 3 (8–9): 1071–9. doi:10.1016/j.dnarep.2004.03.034. PMID 15279795.
• Zhang Z, Wang H, Li M, Rayburn E, Agrawal S, Zhang R (2006). "Novel MDM2 p53-independent functions identified through RNA silencing technologies". Ann. N. Y. Acad. Sci. 1058 (1): 205–14. doi:10.1196/annals.1359.030. PMID 16394138. S2CID 35683657.
• Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G (July 2009). "PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells". Mol. Carcinog. 48 (12): 1149–58. doi:10.1002/mc.20569. PMID 19603422. S2CID 41545085.

External links

• E2F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook E2F1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.