DTX2: Difference between revisions
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{{PBB|geneid=113878}} |
{{PBB|geneid=113878}} |
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'''Protein deltex-2''' is a [[ |
'''Protein deltex-2''' also known as '''E3 ubiquitin-protein ligase DTX2''' is a [[enzyme]] that in humans is encoded by the ''DTX2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DTX2 deltex homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113878| accessdate = }}</ref> |
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DTX2 functions as a [[Ubiquitin_ligase#Individual_E3_ubiquitin_ligases|ubiquitin E3 ligase]] in conjunction with the E2 enzyme [[UBE2D1|UBCH5A]].<ref name="pmid12670957">{{cite journal | author = Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA | title = The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21930–7 | year = 2003 | pmid = 12670957 | doi = 10.1074/jbc.M301157200 }}</ref> |
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==References== |
==References== |
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*{{cite journal | author=Kishi N |title=Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis |journal=Int. J. Dev. Neurosci. |volume=19 |issue= 1 |pages= 21–35 |year= 2001 |pmid= 11226752 |doi=10.1016/S0736-5748(00)00071-X | author-separator=, | author2=Tang Z | author3=Maeda Y | display-authors=3 | last4=Hirai | first4=Asami | last5=Mo | first5=Rong | last6=Ito | first6=Mikiko | last7=Suzuki | first7=Satoshi | last8=Nakao | first8=Keiko | last9=Kinoshita | first9=Tsutomu }} |
*{{cite journal | author=Kishi N |title=Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis |journal=Int. J. Dev. Neurosci. |volume=19 |issue= 1 |pages= 21–35 |year= 2001 |pmid= 11226752 |doi=10.1016/S0736-5748(00)00071-X | author-separator=, | author2=Tang Z | author3=Maeda Y | display-authors=3 | last4=Hirai | first4=Asami | last5=Mo | first5=Rong | last6=Ito | first6=Mikiko | last7=Suzuki | first7=Satoshi | last8=Nakao | first8=Keiko | last9=Kinoshita | first9=Tsutomu }} |
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*{{cite journal | author=Yamamoto N |title=Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45031–40 |year= 2002 |pmid= 11564735 |doi= 10.1074/jbc.M105245200 | author-separator=, | author2=Yamamoto S | author3=Inagaki F | display-authors=3 | last4=Kawaichi | first4=M | last5=Fukamizu | first5=A | last6=Kishi | first6=N | last7=Matsuno | first7=K | last8=Nakamura | first8=K | last9=Weinmaster | first9=G }} |
*{{cite journal | author=Yamamoto N |title=Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45031–40 |year= 2002 |pmid= 11564735 |doi= 10.1074/jbc.M105245200 | author-separator=, | author2=Yamamoto S | author3=Inagaki F | display-authors=3 | last4=Kawaichi | first4=M | last5=Fukamizu | first5=A | last6=Kishi | first6=N | last7=Matsuno | first7=K | last8=Nakamura | first8=K | last9=Weinmaster | first9=G }} |
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*{{cite journal | author=Takeyama K |title=The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21930–7 |year= 2003 |pmid= 12670957 |doi= 10.1074/jbc.M301157200 | author-separator=, | author2=Aguiar RC | author3=Gu L | display-authors=3 | last4=He | first4=C | last5=Freeman | first5=GJ | last6=Kutok | first6=JL | last7=Aster | first7=JC | last8=Shipp | first8=MA }} |
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*{{cite journal | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 | author-separator=, | author2=Muster N | author3=Koch HB | display-authors=3 | last4=Yates Jr | first4=3rd | last5=Hermeking | first5=H }} |
*{{cite journal | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 | author-separator=, | author2=Muster N | author3=Koch HB | display-authors=3 | last4=Yates Jr | first4=3rd | last5=Hermeking | first5=H }} |
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*{{cite journal | author=Hiller M |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 | pmc=1380236 | author-separator=, | author2=Huse K | author3=Szafranski K | display-authors=3 | last4=Jahn | first4=Niels | last5=Hampe | first5=Jochen | last6=Schreiber | first6=Stefan | last7=Backofen | first7=Rolf | last8=Platzer | first8=Matthias }} |
*{{cite journal | author=Hiller M |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 | pmc=1380236 | author-separator=, | author2=Huse K | author3=Szafranski K | display-authors=3 | last4=Jahn | first4=Niels | last5=Hampe | first5=Jochen | last6=Schreiber | first6=Stefan | last7=Backofen | first7=Rolf | last8=Platzer | first8=Matthias }} |
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Revision as of 19:41, 20 May 2014
Template:PBB Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is a enzyme that in humans is encoded by the DTX2 gene.[1]
DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.[2]
References
- ^ "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
- ^ Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
Further reading
- Matsuno K; Diederich RJ; Go MJ; et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. PMID 7671825.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Kishi N; Tang Z; Maeda Y; et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Yamamoto N; Yamamoto S; Inagaki F; et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
{{cite journal}}: Unknown parameter|author-separator=ignored (help)CS1 maint: unflagged free DOI (link) - Benzinger A; Muster N; Koch HB; et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
{{cite journal}}: Unknown parameter|author-separator=ignored (help)CS1 maint: numeric names: authors list (link) CS1 maint: unflagged free DOI (link) - Hiller M; Huse K; Szafranski K; et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC 1380236. PMID 16400609.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Lim J; Hao T; Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID 17286044.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- DTX2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.