Sterol regulatory element-binding protein 1

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SREBF1
Protein SREBF1 PDB 1am9.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SREBF1, SREBP-1c, SREBP1, bHLHd1, SREBP1a, sterol regulatory element binding transcription factor 1
External IDs MGI: 107606 HomoloGene: 3079 GeneCards: 6720
RNA expression pattern
PBB GE SREBF1 202308 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005291
NM_004176
NM_001321096

NM_011480
NM_001313979

RefSeq (protein)

NP_001005291.1
NP_004167.3

NP_001300908.1
NP_035610.1

Location (UCSC) Chr 17: 17.81 – 17.84 Mb Chr 11: 60.2 – 60.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.[3][4]

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.[5] The isoforms are SREBP-1a and -1c (ADD-1).

Function[edit]

The proteins encoded by this gene are transcription factors that bind to a sequence in the promoter of different genes, called sterol regulatory element-1 (SRE1). This element is a decamer flanking the LDL receptor gene and other genes involved in, for instance, sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.

SREBP-1c regulates genes required for glucose metabolism and fatty acid and lipid production and its expression is regulated by insulin.[6] SREBP-1a regulates genes related to lipid and cholesterol production and its activity is regulated by sterol levels in the cell.[7]

Interactions[edit]

SREBF1 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (Oct 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell. 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897. 
  4. ^ Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH (Feb 1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics. 25 (3): 667–73. doi:10.1016/0888-7543(95)80009-B. PMID 7759101. 
  5. ^ "Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1". 
  6. ^ Ferré P, Foufelle F (Oct 2010). "Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c". Diabetes, Obesity & Metabolism. 12 Suppl 2 (Suppl 2): 83–92. doi:10.1111/j.1463-1326.2010.01275.x. PMID 21029304. 
  7. ^ Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F (Nov 2004). "SREBP transcription factors: master regulators of lipid homeostasis". Biochimie. 86 (11): 839–48. doi:10.1016/j.biochi.2004.09.018. PMID 15589694. 
  8. ^ Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891. 
  9. ^ Lopez D, Shea-Eaton W, Sanchez MD, McLean MP (Dec 2001). "DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1". Endocrinology. 142 (12): 5097–106. doi:10.1210/endo.142.12.8523. PMID 11713202. 
  10. ^ Lloyd DJ, Trembath RC, Shackleton S (Apr 2002). "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies". Human Molecular Genetics. 11 (7): 769–77. doi:10.1093/hmg/11.7.769. PMID 11929849. 
  11. ^ Lee YS, Lee HH, Park J, Yoo EJ, Glackin CA, Choi YI, Jeon SH, Seong RH, Park SD, Kim JB (Dec 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Research. 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMC 291873free to read. PMID 14654692. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.