From Wikipedia, the free encyclopedia
Jump to: navigation, search
Lymphoblastic leukemia associated hematopoiesis regulator 1
Symbols LYL1 ; bHLHa18
External IDs OMIM151440 MGI96891 HomoloGene4078 GeneCards: LYL1 Gene
RNA expression pattern
PBB GE LYL1 210044 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4066 17095
Ensembl ENSG00000104903 ENSMUSG00000034041
UniProt P12980 P27792
RefSeq (mRNA) NM_005583 NM_008535
RefSeq (protein) NP_005574 NP_032561
Location (UCSC) Chr 19:
13.1 – 13.1 Mb
Chr 8:
84.7 – 84.7 Mb
PubMed search [1] [2]

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.[1][2]


LYL1 has been shown to interact with TCF3[3] and NFKB1.[4]


  1. ^ Mellentin JD, Smith SD, Cleary ML (Aug 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. 
  2. ^ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1". 
  3. ^ Miyamoto, A; Cui X; Naumovski L; Cleary M L (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. (UNITED STATES) 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. ISSN 0270-7306. PMC 231228. PMID 8628307. 
  4. ^ Ferrier, R; Nougarede R; Doucet S; Kahn-Perles B; Imbert J; Mathieu-Mahul D (Jan 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene (ENGLAND) 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. ISSN 0950-9232. PMID 10023675. 

Further reading[edit]

External links[edit]