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Homeobox D4
Symbols HOXD4 ; HHO.C13; HOX-5.1; HOX4; HOX4B; Hox-4.2
External IDs OMIM142981 MGI96208 HomoloGene7773 GeneCards: HOXD4 Gene
Species Human Mouse
Entrez 3233 15436
Ensembl ENSG00000170166 ENSMUSG00000101174
UniProt P09016 P10628
RefSeq (mRNA) NM_014621 NM_010469
RefSeq (protein) NP_055436 NP_034599
Location (UCSC) Chr 2:
176.15 – 176.15 Mb
Chr 2:
74.71 – 74.73 Mb
PubMed search [1] [2]

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.[1][2][3]


This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined.[3]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXD4 homeobox D4". 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.