From Wikipedia, the free encyclopedia
Jump to: navigation, search
TEA domain family member 4
Protein TEAD4 PDB 2hzd.png
PDB rendering based on 2hzd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TEAD4 ; EFTR-2; RTEF1; TCF13L1; TEF-3; TEF3; TEFR-1; hRTEF-1B
External IDs OMIM601714 MGI106907 HomoloGene74463 GeneCards: TEAD4 Gene
RNA expression pattern
PBB GE TEAD4 41037 at tn.png
PBB GE TEAD4 204281 at tn.png
More reference expression data
Species Human Mouse
Entrez 7004 21679
Ensembl ENSG00000197905 ENSMUSG00000030353
UniProt Q15561 Q62296
RefSeq (mRNA) NM_003213 NM_001080979
RefSeq (protein) NP_003204 NP_001074448
Location (UCSC) Chr 12:
2.96 – 3.04 Mb
Chr 6:
128.22 – 128.3 Mb
PubMed search [1] [2]

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[1][2][3]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[4] It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[3]


  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009. 
  2. ^ Stewart AF, Richard CW 3rd, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (Feb 1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68–76. doi:10.1006/geno.1996.0522. PMID 8921372. 
  3. ^ a b "Entrez Gene: TEAD4 TEA domain family member 4". 
  4. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. 

Further reading[edit]

External links[edit]