REL

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REL
Identifiers
Aliases REL, C-Rel, REL proto-oncogene, NF-kB subunit
External IDs MGI: 97897 HomoloGene: 2182 GeneCards: REL
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for REL
Genomic location for REL
Band 2p16.1 Start 60,881,521 bp[1]
End 60,931,610 bp[1]
RNA expression pattern
PBB GE REL 206036 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291746
NM_002908

NM_009044

RefSeq (protein)

NP_001278675
NP_002899

NP_033070

Location (UCSC) Chr 2: 60.88 – 60.93 Mb Chr 2: 23.74 – 23.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[5] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162924 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020275 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. PMID 1577270. doi:10.1101/gad.6.5.745. 
  6. ^ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. PMID 14755244. doi:10.1038/sj.onc.1207410. 

Further reading[edit]

External links[edit]