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V-rel avian reticuloendotheliosis viral oncogene homolog
Symbols REL ; C-Rel
External IDs OMIM164910 MGI97897 HomoloGene2182 GeneCards: REL Gene
RNA expression pattern
PBB GE REL 206036 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5966 19696
Ensembl ENSG00000162924 ENSMUSG00000020275
UniProt Q04864 P15307
RefSeq (mRNA) NM_001291746 NM_009044
RefSeq (protein) NP_001278675 NP_033070
Location (UCSC) Chr 2:
60.88 – 60.93 Mb
Chr 11:
23.74 – 23.77 Mb
PubMed search [1] [2]

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[1] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[2]


  1. ^ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270. 
  2. ^ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene 23 (13): 2275–86. doi:10.1038/sj.onc.1207410. PMID 14755244. 

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