HOXB5

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HOXB5
Protein HOXB5 PDB 1hom.png
Identifiers
Aliases HOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1, homeobox B5
External IDs MGI: 96186 HomoloGene: 37585 GeneCards: 3215
RNA expression pattern
PBB GE HOXB5 205600 x at tn.png

PBB GE HOXB5 205601 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002147

NM_008268

RefSeq (protein)

NP_002138.1

NP_032294.2

Location (UCSC) Chr 17: 48.59 – 48.59 Mb Chr 11: 96.3 – 96.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[1][2][3]

Function[edit]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[3]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB5 homeobox B5". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.