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Homeobox B5
Protein HOXB5 PDB 1hom.png
PDB rendering based on 1hom.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HOXB5 ; HHO.C10; HOX2; HOX2A; HU-1; Hox2.1
External IDs OMIM142960 MGI96186 HomoloGene37585 GeneCards: HOXB5 Gene
RNA expression pattern
PBB GE HOXB5 205601 s at tn.png
PBB GE HOXB5 205600 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3215 15413
Ensembl ENSG00000120075 ENSMUSG00000038700
UniProt P09067 P09079
RefSeq (mRNA) NM_002147 NM_008268
RefSeq (protein) NP_002138 NP_032294
Location (UCSC) Chr 17:
48.59 – 48.59 Mb
Chr 11:
96.3 – 96.31 Mb
PubMed search [1] [2]

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[3]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB5 homeobox B5". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.