BACH2

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BTB and CNC homology 1, basic leucine zipper transcription factor 2
3ohu.png
Crystal structure of the human Bach2 BTB/POZ domain dimer. PDB entry 3ohu[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BACH2 ; BTBD25
External IDs OMIM605394 HomoloGene7240 GeneCards: BACH2 Gene
RNA expression pattern
PBB GE BACH2 221234 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 60468 12014
Ensembl ENSG00000112182 ENSMUSG00000040270
UniProt Q9BYV9 P97303
RefSeq (mRNA) NM_001170794 NM_001109661
RefSeq (protein) NP_001164265 NP_001103131
Location (UCSC) Chr 6:
89.93 – 90.3 Mb
Chr 4:
32.24 – 32.59 Mb
PubMed search [1] [2]

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.[2][3][4] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [5] and a bZip_Maf domain at the C-terminus.

Model organisms[edit]

Model organisms have been used in the study of BACH2 function. A conditional knockout mouse line called Bach2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12] - in-depth bone and cartilage phenotyping[13]





References[edit]

  1. ^ Rosbrook, G. O.; Stead, M. A.; Carr, S. B.; Wright, S. C. (2011). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica Section D Biological Crystallography 68 (Pt 1): 26–34. doi:10.1107/S0907444911048335. PMID 22194330.  edit
  2. ^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T et al. (Aug 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928. 
  3. ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K et al. (Nov 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606. 
  4. ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". 
  5. ^ Rosbrook GO, Stead MA, Carr SB, Wright SC (Jan 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica. Section D, Biological Crystallography 68 (Pt 1): 26–34. doi:10.1107/S0907444911048335. PMID 22194330. 
  6. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  7. ^ a b "International Mouse Phenotyping Consortium". 
  8. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337â€"42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  9. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9â€"13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  12. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 
  13. ^ a b "OBCD Consortium". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.