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BTB and CNC homology 1, basic leucine zipper transcription factor 2
Crystal structure of the human Bach2 BTB/POZ domain dimer. PDB entry 3ohu[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols BACH2 ; BTBD25
External IDs OMIM605394 HomoloGene7240 GeneCards: BACH2 Gene
RNA expression pattern
PBB GE BACH2 221234 s at tn.png
More reference expression data
Species Human Mouse
Entrez 60468 12014
Ensembl ENSG00000112182 ENSMUSG00000040270
UniProt Q9BYV9 P97303
RefSeq (mRNA) NM_001170794 NM_001109661
RefSeq (protein) NP_001164265 NP_001103131
Location (UCSC) Chr 6:
89.93 – 90.3 Mb
Chr 4:
32.24 – 32.59 Mb
PubMed search [1] [2]

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.[2][3][4] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [5] and a bZip_Maf domain at the C-terminus.

Model organisms[edit]

Model organisms have been used in the study of BACH2 function. A conditional knockout mouse line called Bach2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12] - in-depth bone and cartilage phenotyping[13]


  1. ^ Rosbrook, G. O.; Stead, M. A.; Carr, S. B.; Wright, S. C. (2011). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica Section D Biological Crystallography 68 (Pt 1): 26–34. doi:10.1107/S0907444911048335. PMID 22194330.  edit
  2. ^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (Aug 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928. 
  3. ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (Nov 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606. 
  4. ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". 
  5. ^ Rosbrook GO, Stead MA, Carr SB, Wright SC (Jan 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica. Section D, Biological Crystallography 68 (Pt 1): 26–34. doi:10.1107/S0907444911048335. PMID 22194330. 
  6. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  7. ^ a b "International Mouse Phenotyping Consortium". 
  8. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337â€"42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  9. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9â€"13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  12. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 
  13. ^ a b "OBCD Consortium". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.