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Homeobox B9
Symbols HOXB9 ; HOX-2.5; HOX2; HOX2E
External IDs OMIM142964 MGI96190 HomoloGene7367 GeneCards: HOXB9 Gene
RNA expression pattern
PBB GE HOXB9 216417 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3219 15417
Ensembl ENSG00000170689 ENSMUSG00000020875
UniProt P17482 P20615
RefSeq (mRNA) NM_024017 NM_008270
RefSeq (protein) NP_076922 NP_032296
Location (UCSC) Chr 17:
48.62 – 48.63 Mb
Chr 11:
96.27 – 96.28 Mb
PubMed search [1] [2]

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[1][2][3]


This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[3]


HOXB9 has been shown to interact with BTG2[4] and BTG1.[4]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB9 homeobox B9". 
  4. ^ a b Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.