HOXB9

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HOXB9
Identifiers
Aliases HOXB9, HOX-2.5, HOX2, HOX2E, homeobox B9
External IDs MGI: 96190 HomoloGene: 7367 GeneCards: HOXB9
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HOXB9
Genomic location for HOXB9
Band 17q21.32 Start 48,621,159 bp[1]
End 48,626,356 bp[1]
RNA expression pattern
PBB GE HOXB9 216417 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024017

NM_008270

RefSeq (protein)

NP_076922

NP_032296

Location (UCSC) Chr 17: 48.62 – 48.63 Mb Chr 17: 96.27 – 96.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[5][6][7]

Function[edit]

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[7]

Interactions[edit]

HOXB9 has been shown to interact with BTG2[8] and BTG1.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170689 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020875 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  6. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  7. ^ a b "Entrez Gene: HOXB9 homeobox B9". 
  8. ^ a b Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. PMID 10617598. doi:10.1074/jbc.275.1.147. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.