This gene encodes a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Paull TT, Haykinson MJ, Johnson RC (Aug 1993). "The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures". Genes & Development. 7 (8): 1521–34. doi:10.1101/gad.7.8.1521. PMID8339930.
Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullrdiek J (Jan 1996). "Mapping of the human HMG2 gene to 4q31". Genomics. 31 (2): 264–5. doi:10.1006/geno.1996.0046. PMID8824816.
Nagaki S, Yamamoto M, Yumoto Y, Shirakawa H, Yoshida M, Teraoka H (May 1998). "Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks". Biochemical and Biophysical Research Communications. 246 (1): 137–41. doi:10.1006/bbrc.1998.8589. PMID9600082.
Yumoto Y, Shirakawa H, Yoshida M, Suwa A, Watanabe F, Teraoka H (Sep 1998). "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro". Journal of Biochemistry. 124 (3): 519–27. doi:10.1093/oxfordjournals.jbchem.a022143. PMID9722660.
Butteroni C, De Felici M, Schöler HR, Pesce M (Dec 2000). "Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins". Journal of Molecular Biology. 304 (4): 529–40. doi:10.1006/jmbi.2000.4238. PMID11099378.
Stros M, Ozaki T, Bacikova A, Kageyama H, Nakagawara A (Mar 2002). "HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter". The Journal of Biological Chemistry. 277 (9): 7157–64. doi:10.1074/jbc.M110233200. PMID11748232.
Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J (Feb 2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A". Nature Immunology. 4 (2): 145–53. doi:10.1038/ni885. PMID12524539.
Lv X, Xu DD, Liu DP, Li L, Hao DL, Liang CC (2003). "High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster". Biochemistry and Cell Biology. 80 (6): 765–70. doi:10.1139/o02-164. PMID12555809.