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High mobility group box 2
Protein HMGB2 PDB 1ckt.png
PDB rendering based on 1ckt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HMGB2 ; HMG2
External IDs OMIM163906 MGI96157 HomoloGene37582 GeneCards: HMGB2 Gene
RNA expression pattern
PBB GE HMGB2 208808 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3148 97165
Ensembl ENSG00000164104 ENSMUSG00000054717
UniProt P26583 P30681
RefSeq (mRNA) NM_001130688 NM_008252
RefSeq (protein) NP_001124160 NP_032278
Location (UCSC) Chr 4:
173.33 – 173.34 Mb
Chr 8:
57.51 – 57.52 Mb
PubMed search [1] [2]

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.[1][2]


This gene encodes a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[2]


  1. ^ Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Dec 1991). "Sequence of human HMG2 cDNA". Nucleic Acids Research 19 (23): 6643. doi:10.1093/nar/19.23.6643. PMC 329240. PMID 1754403. 
  2. ^ a b "Entrez Gene: HMGB2 high-mobility group box 2". 

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