This gene encodes a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Paull TT, Haykinson MJ, Johnson RC (1993). "The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.". Genes Dev.7 (8): 1521–34. doi:10.1101/gad.7.8.1521. PMID8339930.
Nagaki S, Yamamoto M, Yumoto Y et al. (1998). "Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.". Biochem. Biophys. Res. Commun.246 (1): 137–41. doi:10.1006/bbrc.1998.8589. PMID9600082.
Yumoto Y, Shirakawa H, Yoshida M et al. (1998). "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro.". J. Biochem.124 (3): 519–27. doi:10.1093/oxfordjournals.jbchem.a022143. PMID9722660.
Butteroni C, De Felici M, Schöler HR, Pesce M (2001). "Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins.". J. Mol. Biol.304 (4): 529–40. doi:10.1006/jmbi.2000.4238. PMID11099378.
Stros M, Ozaki T, Bacikova A et al. (2002). "HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.". J. Biol. Chem.277 (9): 7157–64. doi:10.1074/jbc.M110233200. PMID11748232.
Fan Z, Beresford PJ, Zhang D et al. (2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.". Nat. Immunol.4 (2): 145–53. doi:10.1038/ni885. PMID12524539.
Lv X, Xu DD, Liu DP et al. (2003). "High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster.". Biochem. Cell Biol.80 (6): 765–70. doi:10.1139/o02-164. PMID12555809.