HMGB2

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HMGB2
Protein HMGB2 PDB 1ckt.png
Identifiers
AliasesHMGB2, HMG2, high mobility group box 2
External IDsMGI: 96157 HomoloGene: 37582 GeneCards: HMGB2
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HMGB2
Genomic location for HMGB2
Band4q34.1Start173,331,695 bp[1]
End173,335,125 bp[1]
RNA expression pattern
PBB GE HMGB2 208808 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002129
NM_001130688
NM_001130689

NM_008252
NM_001363443
NM_001363444
NM_001363445

RefSeq (protein)

NP_001124160
NP_001124161
NP_002120

NP_032278
NP_001350372
NP_001350373
NP_001350374

Location (UCSC)Chr 4: 173.33 – 173.34 MbChr 8: 57.51 – 57.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.[5][6]

Function[edit]

This gene encodes a member of the non-histone chromosomal high-mobility group protein family.[7] The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164104 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054717 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Dec 1991). "Sequence of human HMG2 cDNA". Nucleic Acids Research. 19 (23): 6643. doi:10.1093/nar/19.23.6643. PMC 329240. PMID 1754403.
  6. ^ a b "Entrez Gene: HMGB2 high-mobility group box 2".
  7. ^ Murugesapillai D, McCauley MJ, Maher LJ, Williams MC (15 November 2016). "Single-molecule studies of high-mobility group B architectural DNA bending proteins". Biophysical Reviews. doi:10.1007/s12551-016-0236-4. PMC 5331113.

Further reading[edit]

External links[edit]