HMGB2

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HMGB2
Protein HMGB2 PDB 1ckt.png
Identifiers
Aliases HMGB2, HMG2, high mobility group box 2
External IDs MGI: 96157 HomoloGene: 37582 GeneCards: HMGB2
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HMGB2
Genomic location for HMGB2
Band 4q34.1 Start 173,331,695 bp[1]
End 173,335,125 bp[1]
RNA expression pattern
PBB GE HMGB2 208808 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002129
NM_001130688
NM_001130689

NM_008252

RefSeq (protein)

NP_001124160
NP_001124161
NP_002120

NP_032278

Location (UCSC) Chr 4: 173.33 – 173.34 Mb Chr 4: 57.51 – 57.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.[5][6]

Function[edit]

This gene encodes a member of the non-histone chromosomal high-mobility group protein family.[7] The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164104 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054717 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Dec 1991). "Sequence of human HMG2 cDNA". Nucleic Acids Research. 19 (23): 6643. PMC 329240Freely accessible. PMID 1754403. doi:10.1093/nar/19.23.6643. 
  6. ^ a b "Entrez Gene: HMGB2 high-mobility group box 2". 
  7. ^ Murugesapillai D, McCauley MJ, Maher LJ, Williams MC (15 November 2016). "Single-molecule studies of high-mobility group B architectural DNA bending proteins". Biophysical Reviews. doi:10.1007/s12551-016-0236-4. 

Further reading[edit]

External links[edit]