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Paired box 4
Symbols PAX4 ; KPD; MODY9
External IDs OMIM167413 MGI97488 HomoloGene4515 GeneCards: PAX4 Gene
RNA expression pattern
PBB GE PAX4 207867 at tn.png
PBB GE PAX4 211176 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5078 18506
Ensembl ENSG00000106331 ENSMUSG00000029706
UniProt O43316 P32115
RefSeq (mRNA) NM_006193 NM_001159925
RefSeq (protein) NP_006184 NP_001153397
Location (UCSC) Chr 7:
127.61 – 127.62 Mb
Chr 6:
28.44 – 28.45 Mb
PubMed search [1] [2]

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.[1][2][3]


This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.[1]

See also[edit]


  1. ^ a b "Entrez Gene: PAX4 paired box gene 4". 
  2. ^ Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (Jan 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochemical and Biophysical Research Communications 242 (1): 176–80. doi:10.1006/bbrc.1997.7935. PMID 9439631. 
  3. ^ Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (Feb 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochemical and Biophysical Research Communications 243 (2): 628–33. doi:10.1006/bbrc.1998.8144. PMID 9480859. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.