PAX4

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PAX4
Identifiers
AliasesPAX4, KPD, MODY9, paired box 4
External IDsMGI: 97488 HomoloGene: 4515 GeneCards: PAX4
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for PAX4
Genomic location for PAX4
Band7q32.1Start127,610,292 bp[1]
End127,618,075 bp[1]
RNA expression pattern
PBB GE PAX4 211176 s at fs.png

PBB GE PAX4 207867 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006193
NM_001366110
NM_001366111

NM_001159925
NM_001159926
NM_011038

RefSeq (protein)

NP_006184
NP_001353039
NP_001353040

NP_001153397
NP_001153398
NP_035168

Location (UCSC)Chr 7: 127.61 – 127.62 MbChr 6: 28.44 – 28.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.[5][6][7]

Function[edit]

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106331 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029706 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: PAX4 paired box gene 4".
  6. ^ Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (Jan 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochemical and Biophysical Research Communications. 242 (1): 176–80. doi:10.1006/bbrc.1997.7935. PMID 9439631.
  7. ^ Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (Feb 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochemical and Biophysical Research Communications. 243 (2): 628–33. doi:10.1006/bbrc.1998.8144. PMID 9480859.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.