EHF (gene)

EHF
Identifiers
Aliases	EHF, ESE3, ESE3B, ESEJ, ETS homologous factor
External IDs	OMIM: 605439; MGI: 1270840; HomoloGene: 7301; GeneCards: EHF; OMA:EHF - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p13 Start 34,621,093 bp End 34,661,057 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E2 Start 103,093,778 bp End 103,133,623 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland gingival epithelium seminal vesicula oral cavity bronchial epithelial cell mucosa of sigmoid colon epithelium of nasopharynx skin of thigh vulva mucosa of pharynx Top expressed in lacrimal gland submandibular gland parotid gland prostate lobe of prostate left colon mucosa of urinary bladder transitional epithelium of urinary bladder conjunctival fornix seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component Golgi apparatus nucleoplasm nucleus Biological process multicellular organism development positive regulation of transcription, DNA-templated cell population proliferation epithelial cell proliferation regulation of transcription, DNA-templated epithelial cell differentiation transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26298 13661 Ensembl ENSG00000135373 ENSMUSG00000012350 UniProt Q9NZC4 O70273 RefSeq (mRNA) NM_001206615 NM_001206616 NM_012153 NM_007914 RefSeq (protein) NP_001193544 NP_001193545 NP_036285 NP_001364970 NP_001364971 NP_001364972 NP_001364973 NP_001364974 NP_001364975 NP_001364976 NP_001364977 NP_001364978 NP_001364979 NP_001364980 NP_001364981 NP_001364982 NP_001364983 NP_001364984 NP_001364985 NP_031940 Location (UCSC) Chr 11: 34.62 – 34.66 Mb Chr 2: 103.09 – 103.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.

Further reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References

• Fujikawa M, Katagiri T, Tugores A, et al. (2007). "ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence". Cancer Sci. 98 (9): 1468–75. doi:10.1111/j.1349-7006.2007.00543.x. PMC 11159184. PMID 17627613. S2CID 2539168.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Park C, Lee I, Kang WK (2007). "Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis". Mol. Cancer Ther. 5 (12): 3191–6. doi:10.1158/1535-7163.MCT-06-0570. PMID 17172423.
• Lim JH, Cho JY, Park YB, et al. (2006). "ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites". Biochem. Biophys. Res. Commun. 350 (3): 736–41. doi:10.1016/j.bbrc.2006.09.102. PMID 17027647.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.
• Appel S, Bringmann A, Grünebach F, et al. (2006). "Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs". Blood. 107 (8): 3265–70. doi:10.1182/blood-2005-06-2480. PMID 16380452.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Silverman ES, Baron RM, Palmer LJ, et al. (2003). "Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung". Am. J. Respir. Cell Mol. Biol. 27 (6): 697–704. doi:10.1165/rcmb.2002-0011oc. PMID 12444029.
• Tugores A, Le J, Sorokina I, et al. (2001). "The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades". J. Biol. Chem. 276 (23): 20397–406. doi:10.1074/jbc.M010930200. PMID 11259407.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Kas K, Finger E, Grall F, et al. (2000). "ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1". J. Biol. Chem. 275 (4): 2986–98. doi:10.1074/jbc.275.4.2986. PMID 10644770.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• EHF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.