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Aliases TBX21, T-PET, T-bet, TBET, TBLYM, T-box 21
External IDs MGI: 1888984 HomoloGene: 8353 GeneCards: TBX21
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TBX21
Genomic location for TBX21
Band 17q21.32 Start 47,733,244 bp[1]
End 47,746,119 bp[1]
RNA expression pattern
PBB GE TBX21 220684 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 47.73 – 47.75 Mb Chr 17: 97.1 – 97.12 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[5]


This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[5]

Role in disease[edit]


The transcription factor encoded by TBX21 is T-bet, which regulates the development of naive T lymphocytes. Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop abnormal lung function consistent with asthma. It is thought that TBX21, therefore, may play a role in the development of asthma in humans as well.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073861 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001444 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: TBX21 T-box 21". 
  6. ^ Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, and Weiss ST (Dec 2004). "TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids". PNAS. 101 (52): 18099–18104. PMC 539815Freely accessible. PMID 15604153. doi:10.1073/pnas.0408532102. 

Further reading[edit]

External links[edit]