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T-box 21
Symbols TBX21 ; T-PET; T-bet; TBET; TBLYM
External IDs OMIM604895 MGI1888984 HomoloGene8353 GeneCards: TBX21 Gene
RNA expression pattern
PBB GE TBX21 220684 at tn.png
More reference expression data
Species Human Mouse
Entrez 30009 57765
Ensembl ENSG00000073861 ENSMUSG00000001444
UniProt Q9UL17 Q9JKD8
RefSeq (mRNA) NM_013351 NM_019507
RefSeq (protein) NP_037483 NP_062380
Location (UCSC) Chr 17:
47.73 – 47.75 Mb
Chr 11:
97.1 – 97.12 Mb
PubMed search [1] [2]

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[1]


This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]


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