TLX1

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TLX1
Identifiers
Aliases TLX1, HOX11, TCL3, T-cell leukemia homeobox 1
External IDs MGI: 98769 HomoloGene: 4031 GeneCards: TLX1
RNA expression pattern
PBB GE TLX1 207179 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195517
NM_005521

NM_021901

RefSeq (protein)

NP_001182446
NP_005512

n/a

Location (UCSC) Chr 10: 101.13 – 101.14 Mb Chr 19: 45.15 – 45.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.[3][4][5][6][7]

Interactions[edit]

TLX1 has been shown to interact with PPP1CC,[8] PPP2CB[8] and PPP2CA.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. doi:10.1126/science.1676542. PMID 1676542. 
  4. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  5. ^ "Entrez Gene: TLX1 T-cell leukemia homeobox 1". 
  6. ^ Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618Freely accessible. PMID 1681546. 
  7. ^ Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. PMID 1683261. 
  8. ^ a b c Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. 

Further reading[edit]