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AliasesTLX1, HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1
External IDsOMIM: 186770 MGI: 98769 HomoloGene: 4031 GeneCards: TLX1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TLX1
Genomic location for TLX1
Band10q24.31Start101,131,300 bp[1]
End101,137,789 bp[1]
RNA expression pattern
PBB GE TLX1 207179 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 101.13 – 101.14 MbChr 19: 45.15 – 45.16 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.[5][6][7][8][9]


TLX1 has been shown to interact with PPP1CC,[10] PPP2CB[10] and PPP2CA.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107807 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025215 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. doi:10.1126/science.1676542. PMID 1676542.
  6. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  7. ^ "Entrez Gene: TLX1 T-cell leukemia homeobox 1".
  8. ^ Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
  9. ^ Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. PMID 1683261.
  10. ^ a b c Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.

Further reading[edit]