MAF (gene)

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V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Symbols MAF ; AYGRP; CCA4; CTRCT21; c-MAF
External IDs OMIM177075 MGI96909 HomoloGene74552 GeneCards: MAF Gene
RNA expression pattern
PBB GE MAF 206363 at tn.png
PBB GE MAF 209347 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4094 17132
Ensembl ENSG00000178573 ENSMUSG00000055435
UniProt O75444 P54843
RefSeq (mRNA) NM_001031804 NM_001025577
RefSeq (protein) NP_001026974 NP_001020748
Location (UCSC) Chr 16:
79.59 – 79.6 Mb
Chr 8:
115.68 – 115.71 Mb
PubMed search [1] [2]

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.[1][2]


One type, MafA, also known as RIPE3b1,[3] promotes pancreatic development, as well as insulin gene transcription.[4]


MAF has been shown to interact with:


  1. ^ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)". 
  2. ^ Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (October 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7711–5. doi:10.1073/pnas.86.20.7711. PMC 298140. PMID 2554284. 
  3. ^ Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737–42. doi:10.1073/pnas.102168499. PMC 124472. PMID 12011435. 
  4. ^ Melloul D, Marshak S, Cerasi E (March 2002). "Regulation of insulin gene transcription". Diabetologia 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736. 
  5. ^ a b Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (July 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779. 
  6. ^ Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation". Mol. Cell. Biol. 18 (5): 2729–37. PMC 110652. PMID 9566892. 
  7. ^ Huang W, Lu N, Eberspaecher H, De Crombrugghe B (December 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". J. Biol. Chem. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.