MAF (gene)

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V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Identifiers
Symbols MAF ; AYGRP; CCA4; CTRCT21; c-MAF
External IDs OMIM177075 MGI96909 HomoloGene74552 GeneCards: MAF Gene
RNA expression pattern
PBB GE MAF 206363 at tn.png
PBB GE MAF 209347 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4094 17132
Ensembl ENSG00000178573 ENSMUSG00000055435
UniProt O75444 P54843
RefSeq (mRNA) NM_001031804 NM_001025577
RefSeq (protein) NP_001026974 NP_001020748
Location (UCSC) Chr 16:
79.59 – 79.6 Mb
Chr 8:
115.68 – 115.71 Mb
PubMed search [1] [2]

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.[1][2]

Types[edit]

One type, MafA, also known as RIPE3b1,[3] promotes pancreatic development, as well as insulin gene transcription.[4]

Interactions[edit]

MAF has been shown to interact with:

References[edit]

  1. ^ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)". 
  2. ^ Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (Oct 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proceedings of the National Academy of Sciences of the United States of America 86 (20): 7711–5. doi:10.1073/pnas.86.20.7711. PMC 298140. PMID 2554284. 
  3. ^ Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 6737–42. doi:10.1073/pnas.102168499. PMC 124472. PMID 12011435. 
  4. ^ Melloul D, Marshak S, Cerasi E (Mar 2002). "Regulation of insulin gene transcription". Diabetologia 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736. 
  5. ^ a b Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779. 
  6. ^ Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology 18 (5): 2729–37. PMC 110652. PMID 9566892. 
  7. ^ Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733. 

Further reading[edit]

  • Kerppola TK, Curran T (Mar 1994). "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun". Oncogene 9 (3): 675–84. PMID 8108109. 
  • Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273. 
  • Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology 18 (5): 2729–37. PMC 110652. PMID 9566892. 
  • Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried T, Kuehl WM (Jun 1998). "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma". Blood 91 (12): 4457–63. PMID 9616139. 
  • Christodoulopoulos P, Cameron L, Nakamura Y, Lemière C, Muro S, Dugas M, Boulet LP, Laviolette M, Olivenstein R, Hamid Q (Apr 2001). "TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression". The Journal of Allergy and Clinical Immunology 107 (4): 586–91. doi:10.1067/mai.2001.114883. PMID 11295643. 
  • Jamieson RV, Perveen R, Kerr B, Carette M, Yardley J, Heon E, Wirth MG, van Heyningen V, Donnai D, Munier F, Black GC (Jan 2002). "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma". Human Molecular Genetics 11 (1): 33–42. doi:10.1093/hmg/11.1.33. PMID 11772997. 
  • Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779. 
  • Dhakshinamoorthy S, Jaiswal AK (Aug 2002). "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction". Oncogene 21 (34): 5301–12. doi:10.1038/sj.onc.1205642. PMID 12149651. 
  • Cousins DJ, Lee TH, Staynov DZ (Sep 2002). "Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines". Journal of Immunology 169 (5): 2498–506. doi:10.4049/jimmunol.169.5.2498. PMID 12193719. 
  • Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733. 
  • DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG (Jun 2003). "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice". Molecular Vision 9: 288–94. PMID 12835653. 
  • Grimbert P, Valanciute A, Audard V, Pawlak A, Le gouvelo S, Lang P, Niaudet P, Bensman A, Guellaën G, Sahali D (Sep 2003). "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization". The Journal of Experimental Medicine 198 (5): 797–807. doi:10.1084/jem.20030566. PMC 1865475. PMID 12939343. 
  • Valanciuté A, le Gouvello S, Solhonne B, Pawlak A, Grimbert P, Lyonnet L, Hue S, Lang P, Remy P, Salomon R, Bensman A, Guellaën G, Sahali D (Jan 2004). "NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome". Journal of Immunology 172 (1): 688–98. doi:10.4049/jimmunol.172.1.688. PMID 14688382. 
  • Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE (Oct 2003). "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance". Leukemia & Lymphoma 44 (10): 1761–6. doi:10.1080/1042819031000111035. PMID 14692531. 
  • Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM (Feb 2004). "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma". Cancer Cell 5 (2): 191–9. doi:10.1016/S1535-6108(04)00019-4. PMID 14998494. 
  • Cao S, Liu J, Song L, Ma X (Mar 2005). "The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages". Journal of Immunology 174 (6): 3484–92. doi:10.4049/jimmunol.174.6.3484. PMC 2955976. PMID 15749884. 
  • Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, Yamada A, Maeda A, Matsuno F, Hata H, Suzuki A, Imagawa S, Mitsuya H, Esumi H, Koyama A, Yamamoto M, Mori N, Takahashi S (Jan 2006). "Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human". Cancer Research 66 (2): 812–9. doi:10.1158/0008-5472.CAN-05-2154. PMID 16424013. 
  • Vanita V, Singh D, Robinson PN, Sperling K, Singh JR (Mar 2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family". American Journal of Medical Genetics. Part A 140 (6): 558–66. doi:10.1002/ajmg.a.31126. PMID 16470690. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.