HOXB4

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HOXB4
Identifiers
Aliases HOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4
External IDs MGI: 96185 HomoloGene: 32095 GeneCards: 3214
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024015

NM_010459

RefSeq (protein)

NP_076920.1

NP_034589.3

Location (UCSC) Chr 17: 48.58 – 48.58 Mb Chr 11: 96.32 – 96.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.[1][2][3]

Function[edit]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[3]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB4 homeobox B4". 

Further reading[edit]

  • Petrini M, Quaranta MT, Testa U, Samoggia P, Tritarelli E, Carè A, Cianetti L, Valtieri M, Barletta C, Peschle C (Jul 1992). "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes". Blood 80 (1): 185–93. PMID 1351762. 
  • Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
  • Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
  • Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. 
  • Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652. 
  • Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y (Feb 1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Bodey B, Bodey B, Siegel SE, Kaiser HE (2000). "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment". In Vivo 14 (3): 419–24. PMID 10904875. 
  • Giannola DM, Shlomchik WD, Jegathesan M, Liebowitz D, Abrams CS, Kadesch T, Dancis A, Emerson SG (Nov 2000). "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2". The Journal of Experimental Medicine 192 (10): 1479–90. doi:10.1084/jem.192.10.1479. PMC 2193192. PMID 11085749. 
  • Pan Q, Simpson RU (Apr 2001). "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression". The Journal of Endocrinology 169 (1): 153–9. doi:10.1677/joe.0.1690153. PMID 11250656. 
  • Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930. 
  • Kömüves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C (May 2002). "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". Developmental Dynamics 224 (1): 58–68. doi:10.1002/dvdy.10085. PMID 11984874. 
  • Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK (Aug 2002). "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells". Blood 100 (3): 862–8. doi:10.1182/blood-2002-01-0220. PMID 12130496. 
  • Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag W (Mar 2003). "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation". Blood 101 (5): 1759–68. doi:10.1182/blood-2002-03-0767. PMID 12406897. 
  • Theokli C, Morsi El-Kadi AS, Morgan R (May 2003). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation". Developmental Dynamics 227 (1): 48–55. doi:10.1002/dvdy.10287. PMID 12701098. 
  • Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C (Jun 2003). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Developmental Dynamics 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847. 
  • Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG (Oct 2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.