ZNF74

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ZNF74
Identifiers
Aliases ZNF74, COS52, ZFP520, ZNF520, hZNF7, zinc finger protein 74
External IDs HomoloGene: 88675 GeneCards: 7625
RNA expression pattern
PBB GE ZNF74 205881 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256523
NM_001256524
NM_001256525
NM_003426

n/a

RefSeq (protein)

NP_001243452.1
NP_001243453.1
NP_001243454.1
NP_003417.2

n/a

Location (UCSC) Chr 22: 20.39 – 20.41 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3] Schizophrenia susceptibility has been associated with a mutation in this protein.[4]

Interactions[edit]

ZNF74 has been shown to interact with POLR2A.[5]

References[edit]

  1. ^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ "Entrez Gene: ZNF74 zinc finger protein 74". 
  4. ^ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia" 52 (3): 161–165. 
  5. ^ Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.