TSHZ3

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TSHZ3
Protein TSHZ3 PDB 2dmi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TSHZ3, TSH3, ZNF537, teashirt zinc finger homeobox 3
External IDs MGI: 2442819 HomoloGene: 10835 GeneCards: 57616
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020856

NM_172298

RefSeq (protein)

NP_065907.2

NP_758502.1

Location (UCSC) Chr 19: 31.27 – 31.35 Mb Chr 7: 36.7 – 36.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene.[3] In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz-3 is being studied for its relationship to infant breathing defects in humans.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: TSHZ3 teashirt family zinc finger 3". 
  4. ^ Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L (July 2010). "Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control". J. Neurosci. 30 (28): 9465–76. doi:10.1523/JNEUROSCI.1765-10.2010. PMID 20631175. Lay summaryNew Scientist. 

Further reading[edit]