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Teashirt zinc finger homeobox 3
Protein TSHZ3 PDB 2dmi.png
PDB rendering based on 2dmi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TSHZ3 ; TSH3; ZNF537
External IDs OMIM614119 MGI2442819 HomoloGene10835 GeneCards: TSHZ3 Gene
Species Human Mouse
Entrez 57616 243931
Ensembl ENSG00000121297 ENSMUSG00000021217
UniProt Q63HK5 Q8CGV9
RefSeq (mRNA) NM_020856 NM_172298
RefSeq (protein) NP_065907 NP_758502
Location (UCSC) Chr 19:
31.27 – 31.35 Mb
Chr 7:
36.7 – 36.77 Mb
PubMed search [1] [2]

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene.[1] In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz-3 is being studied for its relationship to infant breathing defects in humans.[2]


  1. ^ "Entrez Gene: TSHZ3 teashirt family zinc finger 3". 
  2. ^ Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L (July 2010). "Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control". J. Neurosci. 30 (28): 9465–76. doi:10.1523/JNEUROSCI.1765-10.2010. PMID 20631175. Lay summaryNew Scientist. 

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