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Nuclear receptor subfamily 2, group F, member 1
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM132890 MGI1352451 HomoloGene21158 IUPHAR: 617 GeneCards: NR2F1 Gene
RNA expression pattern
PBB GE NR2F1 209505 at tn.png
PBB GE NR2F1 209506 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7025 13865
Ensembl ENSG00000175745 ENSMUSG00000069171
UniProt P10589 Q60632
RefSeq (mRNA) NM_005654 NM_010151
RefSeq (protein) NP_005645 NP_034281
Location (UCSC) Chr 5:
93.58 – 93.59 Mb
Chr 13:
78.19 – 78.2 Mb
PubMed search [1] [2]

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.


Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[5]


COUP-TFI has been shown to interact with:


  1. ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1". 
  2. ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078. 
  3. ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (1 December 1986). "Identification of two factors required for transcription of the ovalbumin gene". Mol. Cell. Biol. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602. 
  4. ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (August 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. 
  5. ^ Tsai SY, Tsai MJ (April 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocr. Rev. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138. 
  6. ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719. 
  7. ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1 May 1999). "Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 84131. PMID 10207062. 
  8. ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (July 2002). "Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.