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Aliases E2F3, E2F-3, E2F transcription factor 3
External IDs MGI: 1096340 HomoloGene: 74413 GeneCards: E2F3
RNA expression pattern
PBB GE E2F3 203692 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 20.4 – 20.49 Mb Chr 13: 29.91 – 29.99 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.[3]


The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.[4]


E2F3 has been shown to interact with TFE3[5] and RYBP.[6]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853Freely accessible. PMID 8246996. 
  4. ^ "Entrez Gene: E2F3 E2F transcription factor 3". 
  5. ^ Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Molecular and Cellular Biology. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231Freely accessible. PMID 12748276. 
  6. ^ Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074Freely accessible. PMID 12411495. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.