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E2F transcription factor 3
Symbols E2F3 ; E2F-3
External IDs OMIM600427 MGI1096340 HomoloGene74413 GeneCards: E2F3 Gene
RNA expression pattern
PBB GE E2F3 203692 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1871 13557
Ensembl ENSG00000112242 ENSMUSG00000016477
UniProt O00716 O35261
RefSeq (mRNA) NM_001243076 NM_001289920
RefSeq (protein) NP_001230005 NP_001276849
Location (UCSC) Chr 6:
20.4 – 20.49 Mb
Chr 13:
29.91 – 29.99 Mb
PubMed search [1] [2]

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.[1]


The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.[2]


E2F3 has been shown to interact with TFE3[3] and RYBP.[4]

See also[edit]


  1. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996. 
  2. ^ "Entrez Gene: E2F3 E2F transcription factor 3". 
  3. ^ Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Molecular and Cellular Biology 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231. PMID 12748276. 
  4. ^ Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.