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Mesenchyme homeobox 2
Symbols MEOX2 ; GAX; MOX2
External IDs OMIM600535 MGI103219 HomoloGene4330 GeneCards: MEOX2 Gene
RNA expression pattern
PBB GE MEOX2 206201 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4223 17286
Ensembl ENSG00000106511 ENSMUSG00000036144
UniProt P50222 P32443
RefSeq (mRNA) NM_005924 NM_008584
RefSeq (protein) NP_005915 NP_032610
Location (UCSC) Chr 7:
15.61 – 15.69 Mb
Chr 12:
37.11 – 37.18 Mb
PubMed search [1] [2]

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[1][2]


This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2]


MEOX2 has been shown to interact with PAX1[3] and PAX3.[3]


  1. ^ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505. 
  2. ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2". 
  3. ^ a b Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.