MEOX2

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MEOX2
Identifiers
Aliases MEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDs MGI: 103219 HomoloGene: 4330 GeneCards: 4223
RNA expression pattern
PBB GE MEOX2 206201 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005924

NM_008584

RefSeq (protein)

NP_005915.2

NP_032610.1

Location (UCSC) Chr 7: 15.61 – 15.69 Mb Chr 12: 37.11 – 37.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[1][2]

Function[edit]

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2]

Interactions[edit]

MEOX2 has been shown to interact with PAX1[3] and PAX3.[3]

References[edit]

  1. ^ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505. 
  2. ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2". 
  3. ^ a b Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.