Germ cell nuclear factor

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Nuclear receptor subfamily 6, group A, member 1
Symbols NR6A1 ; CT150; GCNF; GCNF1; NR61; RTR; hGCNF; hRTR
External IDs OMIM602778 MGI1352459 HomoloGene36308 IUPHAR: 634 GeneCards: NR6A1 Gene
RNA expression pattern
PBB GE NR6A1 207742 s at tn.png
PBB GE NR6A1 210391 at tn.png
PBB GE NR6A1 210392 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2649 14536
Ensembl ENSG00000148200 ENSMUSG00000063972
UniProt Q15406 Q64249
RefSeq (mRNA) NM_001278546 NM_001159548
RefSeq (protein) NP_001265475 NP_001153020
Location (UCSC) Chr 9:
124.52 – 124.77 Mb
Chr 2:
38.72 – 38.93 Mb
PubMed search [1] [2]

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.[1][2] GCNF is a member of the nuclear receptor family of intracellular transcription factors .

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.[3]

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.[4]


  1. ^ Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation". Journal of Molecular Endocrinology 18 (2): 167–76. doi:10.1677/jme.0.0180167. PMID 9134503. 
  2. ^ Süsens U, Borgmeyer U (Dec 1996). "Characterization of the human germ cell nuclear factor gene". Biochimica et Biophysica Acta 1309 (3): 179–82. doi:10.1016/s0167-4781(96)00157-1. PMID 8982251. 
  3. ^ Zechel C (Dec 2005). "The germ cell nuclear factor (GCNF)". Molecular Reproduction and Development 72 (4): 550–6. doi:10.1002/mrd.20377. PMID 16155958. 
  4. ^ "Entrez Gene: NR6A1 nuclear receptor subfamily 6, group A, member 1". 

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