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Kruppel-like factor 17
Protein KIFC3 PDB 2h58.png
PDB rendering based on 2h58.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLF17 ; ZNF393; Zfp393
External IDs OMIM609602 MGI109202 HomoloGene12621 ChEMBL: 1075119 GeneCards: KLF17 Gene
RNA expression pattern
PBB GE KIFC3 209661 at tn.png
More reference expression data
Species Human Mouse
Entrez 128209 75753
Ensembl ENSG00000171872 ENSMUSG00000048626
UniProt Q5JT82 Q8CFA7
RefSeq (mRNA) NM_173484 NM_029416
RefSeq (protein) NP_775755 NP_083692
Location (UCSC) Chr 1:
44.58 – 44.6 Mb
Chr 4:
117.76 – 117.77 Mb
PubMed search [1] [2]

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.[1][2]

Model organisms[edit]

Model organisms have been used in the study of KLF17 function. A conditional knockout mouse line called Klf17tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]


  1. ^ van Vliet J, Crofts LA, Quinlan KG, Czolij R, Perkins AC, Crossley M (Mar 2006). "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics 87 (4): 474–82. doi:10.1016/j.ygeno.2005.12.011. PMID 16460907. 
  2. ^ "Entrez Gene: KLF17 Kruppel-like factor 17". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]

External links[edit]