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Kruppel-like factor 17
Protein KIFC3 PDB 2h58.png
PDB rendering based on 2h58.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLF17 ; ZNF393; Zfp393
External IDs OMIM609602 MGI109202 HomoloGene12621 ChEMBL: 1075119 GeneCards: KLF17 Gene
RNA expression pattern
PBB GE KIFC3 209661 at tn.png
More reference expression data
Species Human Mouse
Entrez 128209 75753
Ensembl ENSG00000171872 ENSMUSG00000048626
UniProt Q5JT82 Q8CFA7
RefSeq (mRNA) NM_173484 NM_029416
RefSeq (protein) NP_775755 NP_083692
Location (UCSC) Chr 1:
44.12 – 44.14 Mb
Chr 4:
117.76 – 117.77 Mb
PubMed search [1] [2]

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.[1][2]

Model organisms[edit]

Model organisms have been used in the study of KLF17 function. A conditional knockout mouse line called Klf17tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]


  1. ^ van Vliet J, Crofts LA, Quinlan KG, Czolij R, Perkins AC, Crossley M (Mar 2006). "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics 87 (4): 474–82. doi:10.1016/j.ygeno.2005.12.011. PMID 16460907. 
  2. ^ "Entrez Gene: KLF17 Kruppel-like factor 17". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]

External links[edit]