RFX2

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RFX2
Identifiers
Aliases RFX2, regulatory factor X2
External IDs MGI: 106583 HomoloGene: 30980 GeneCards: RFX2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for RFX2
Genomic location for RFX2
Band No data available Start 5,993,164 bp[1]
End 6,199,572 bp[1]
RNA expression pattern
PBB GE RFX2 208031 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000635
NM_134433

NM_009056
NM_027787

RefSeq (protein)

NP_000626
NP_602309

NP_033082
NP_082063

Location (UCSC) Chr 19: 5.99 – 6.2 Mb Chr 19: 56.78 – 56.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[5][6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087903 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024206 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. PMID 1505960. doi:10.1016/0888-7543(92)90052-T. 
  6. ^ a b "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.