CREB3

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CREB3
Identifiers
AliasesCREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3
External IDsMGI: 99946 HomoloGene: 31375 GeneCards: CREB3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CREB3
Genomic location for CREB3
Band9p13.3Start35,732,335 bp[1]
End35,737,004 bp[1]
RNA expression pattern
PBB GE CREB3 209432 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006368

NM_013497

RefSeq (protein)

NP_006359

n/a

Location (UCSC)Chr 9: 35.73 – 35.74 MbChr 4: 43.56 – 43.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.[5][6]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.[6]

See also[edit]

Interactions[edit]

CREB3 has been shown to interact with Host cell factor C1.[7][8]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.