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CAMP responsive element binding protein 3
External IDs OMIM606443 MGI99946 HomoloGene31375 GeneCards: CREB3 Gene
RNA expression pattern
PBB GE CREB3 209432 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10488 12913
Ensembl ENSG00000107175 ENSMUSG00000028466
UniProt O43889 Q61817
RefSeq (mRNA) NM_006368 NM_013497
RefSeq (protein) NP_006359 NP_038525
Location (UCSC) Chr 9:
35.73 – 35.74 Mb
Chr 4:
43.56 – 43.57 Mb
PubMed search [1] [2]

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.[1][2]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.[2]

See also[edit]


CREB3 has been shown to interact with Host cell factor C1.[3][4]


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.